Olfr455 Inhibitors
Olfactory receptor family 10 subfamily AC member 1 (Or10ac1) is a pivotal component in the intricate sensory system of olfaction. As a member of the olfactory receptor gene family, Or10ac1 plays a fundamental role in initiating the neuronal response that underlies the perception of specific smells. Olfactory receptors, including Or10ac1, are G-protein-coupled receptors (GPCRs) with a characteristic seven-transmembrane domain structure, a common feature shared with neurotransmitter and hormone receptors. Situated in the nasal epithelium, Or10ac1's primary function is to interact with odorant molecules, initiating a cascade of events that lead to the transduction of olfactory signals and the subsequent perception of distinct odors. The olfactory receptor gene family, of which Or10ac1 is a part, stands out as the largest gene family in the genome, underscoring the evolutionary significance and complexity of the olfactory system.
The inhibition of Or10ac1 involves a nuanced interplay of direct and indirect mechanisms targeting specific cellular pathways associated with olfactory signal transduction. Direct inhibitors act by directly modulating factors critical to Or10ac1 function, such as odorant binding, calcium signaling, and the MAPK pathway. Indirect inhibitors, on the other hand, influence downstream signaling pathways, such as the endocannabinoid system, cAMP levels, calcium/calmodulin-dependent protein kinase II (CaMKII), and protein kinase C (PKC), indirectly impacting Or10ac1 function in olfactory signal processing. This intricate network of inhibitors reflects the multifaceted nature of olfactory perception and the underlying molecular processes. Understanding the diverse mechanisms of inhibition not only enhances our comprehension of the regulatory landscape governing olfaction but also opens avenues for further exploration in the field of sensory neuroscience. Unraveling the complexities of Or10ac1 inhibition contributes to the broader understanding of how the olfactory system deciphers and processes a vast array of odorant stimuli, adding depth to the exploration of sensory perception at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ANTU | 86-88-4 | sc-233887 | 1 g | $156.00 | ||
Direct inhibitor of Or10ac1 by binding to its odorant-binding site. α-Naphthylthiourea competitively displaces odorant molecules, preventing their interaction with Or10ac1. This leads to the inhibition of the neuronal response triggered by the perception of specific smells. | ||||||
Rimonabant | 168273-06-1 | sc-205491 sc-205491A | 5 mg 10 mg | $73.00 $163.00 | 15 | |
Indirect inhibitor of Or10ac1 by targeting the endocannabinoid system. Rimonabant inhibits CB1 receptors, downstream of Or10ac1 signaling, reducing cAMP levels. Lower cAMP levels influence the G protein-mediated transduction of odorant signals, indirectly suppressing Or10ac1 function in olfactory signal processing. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Direct inhibitor of Or10ac1 by modulating olfactory signal transduction. Zinc sulfate interferes with the function of adenylate cyclase, reducing cAMP production. Lower cAMP levels disrupt the G protein-mediated transduction of odorant signals, directly inhibiting Or10ac1 and impairing the perception of specific smells. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Direct inhibitor of Or10ac1 by modulating calcium signaling. 2-APB blocks IP3 receptors, reducing intracellular calcium levels. Impaired calcium signaling directly inhibits Or10ac1 function, affecting the downstream events in olfactory signal transduction triggered by the interaction of Or10ac1 with odorant molecules. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Indirect inhibitor of Or10ac1 by targeting calcium/calmodulin-dependent protein kinase II (CaMKII). KN-93 inhibits CaMKII, reducing its activation by intracellular calcium. Lower CaMKII activity indirectly suppresses Or10ac1 by disrupting the calcium-dependent modulation of olfactory signal transduction, impairing the perception of specific smells. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Direct inhibitor of Or10ac1 by modulating the MAPK pathway. PD98059 inhibits MEK1/2, downstream of GPCR signaling, impairing the activation of MAPK. Disrupted MAPK signaling directly inhibits Or10ac1, influencing the neuronal response triggered by the interaction of Or10ac1 with odorant molecules in olfactory signal transduction. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Indirect inhibitor of Or10ac1 by modulating cAMP levels. IBMX inhibits phosphodiesterases, preventing the degradation of cAMP. Increased cAMP levels enhance the G protein-mediated transduction of odorant signals, indirectly amplifying Or10ac1 function in olfactory signal processing. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Direct inhibitor of Or10ac1 by chelating intracellular calcium. BAPTA-AM sequesters intracellular calcium, preventing its interaction with calmodulin. Impaired calcium/calmodulin-dependent processes directly inhibit Or10ac1, disrupting the downstream events in olfactory signal transduction initiated by the activation of Or10ac1 by odorant molecules. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Direct inhibitor of Or10ac1 by targeting phosphoinositide 3-kinase (PI3K). Wortmannin inhibits PI3K, impairing the generation of phosphoinositides. Disrupted PI3K activity directly inhibits Or10ac1, affecting the downstream events in olfactory signal transduction triggered by the interaction of Or10ac1 with odorant molecules. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Indirect inhibitor of Or10ac1 by targeting protein kinase C (PKC). Gö 6983 inhibits PKC, reducing its activation by intracellular signals. Lower PKC activity indirectly suppresses Or10ac1 by disrupting the protein kinase C-mediated modulation of olfactory signal transduction, impairing the perception of specific smells. | ||||||