Olfr424 Inhibitors
The Olfr424 olfactory receptor, a prominent member of the G-protein-coupled receptor (GPCR) family, plays a pivotal role in the initiation of neuronal responses critical for the perception of smells. With its 7-transmembrane domain structure, Olfr424 actively contributes to the recognition and G protein-mediated transduction of odorant signals, intricately participating in the complex network of olfactory perception.
The inhibition of Olfr424 involves a sophisticated interplay of direct and indirect mechanisms. Direct inhibitors, including camphor, hexanal, menthol, decanal, citral, and linalool, act by binding to Olfr424 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, such as eugenol, thymol, isoeugenol, carvone, and methyl anthranilate, modulate the cyclic nucleotide signaling pathway associated with Olfr424. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. This diverse array of inhibitors provides a comprehensive approach to disrupting Olfr424's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirming the efficacy of these inhibitors in practice and further unraveling the intricacies of olfactory signal transduction mediated by Olfr424.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr424. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal serves as a direct inhibitor, binding to Olfr424 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr424. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol functions as a direct inhibitor, binding to Olfr424 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $63.00 $53.00 | ||
Isoeugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr424. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal serves as a direct inhibitor, binding to Olfr424 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
(−)-Carvone | 6485-40-1 | sc-293985 sc-293985A | 25 ml 500 ml | $51.00 $230.00 | 2 | |
Carvone acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr424. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral functions as a direct inhibitor, binding to Olfr424 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool serves as a direct inhibitor, binding to Olfr424 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Benzyl alcohol | 100-51-6 | sc-326216B sc-326216 sc-326216A | 250 ml 1 L 5 L | $32.00 $104.00 $416.00 | ||
Benzyl alcohol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr424. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||