Olfr395 Inhibitors
Or1e35, a member of the olfactory receptor family 1 subfamily E in Mus musculus, plays a crucial role in the intricate process of olfaction. As an olfactory receptor, Or1e35 is tasked with interacting with odorant molecules in the nose, initiating a neuronal response that ultimately leads to the perception of various smells. This receptor, like others in its family, belongs to the G-protein-coupled receptor (GPCR) class and possesses a distinct 7-transmembrane domain structure. This structural feature aligns it with neurotransmitter and hormone receptors, highlighting its role in recognizing and transducing signals from odorants through G protein-mediated mechanisms. The olfactory receptor gene family, including Or1e35, stands as the largest in the mouse genome. Its nomenclature is independent of other organisms, emphasizing the unique nature of olfactory receptors in Mus musculus. Or1e35's function is intricately linked to the recognition and transduction of odorant signals, contributing to the diverse and nuanced olfactory experiences of mice. This receptor's involvement in neuronal responses triggered by odorant molecules underscores its significance in the sensory perception of smells, showcasing the essential role of Or1e35 in the olfactory system.
Inhibition of Or1e35 involves a targeted approach aimed at disrupting specific signaling pathways and cellular processes associated with olfactory signal transduction. The identified inhibitors act on various molecular targets, such as adenylate cyclase, calcium channels, the PI3K-Akt pathway, MAPK pathway, TMBIM6, GABAA receptors, muscarinic acetylcholine receptors, beta-adrenergic receptors, CaMKII, and PKA. These inhibitors modulate key components of olfactory signal transduction, creating a cascade effect that alters neuronal responses. By disrupting the intricate network of molecular interactions associated with Or1e35 activation, these inhibitors prevent the receptor from efficiently transducing odorant signals. The complexity and diversity of the inhibition mechanisms reflect the intricate nature of olfactory signal processing, shedding light on the molecular intricacies underlying Or1e35's function within the broader context of the mouse olfactory receptor family.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol functions as a direct inhibitor by interfering with the binding of odorant molecules to Or1e35. Its inhibitory action disrupts the initiation of the neuronal response, thus impeding the perception of smell mediated by the olfactory receptor. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin acts as an indirect inhibitor by targeting TRPV1 channels linked to Or1e35 signaling. Through modulation of TRPV1, capsaicin influences G protein-mediated transduction, leading to the indirect inhibition of the olfactory receptor and perception of odorant signals. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal serves as a direct inhibitor by disrupting the 7-transmembrane domain structure of Or1e35. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Picrotoxin acts as an indirect inhibitor by influencing the GABAergic signaling pathway associated with Or1e35. Its modulation of GABAergic transmission disrupts the downstream processes linked to olfactory signal transduction, providing an indirect inhibition of the olfactory receptor. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol serves as a direct inhibitor by binding to Or1e35 and interfering with its 7-transmembrane domain structure. This disrupts the receptor's ability to recognize odorant molecules, resulting in the inhibition of the neuronal response and perception of smell mediated by the olfactory receptor. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate functions as a direct inhibitor by interfering with the binding of odorant molecules to Or1e35. Its inhibitory action disrupts the initiation of the neuronal response, thus impeding the perception of smell mediated by the olfactory receptor. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine serves as an indirect inhibitor by modulating sodium channels associated with Or1e35 signaling. Its influence on sodium channels disrupts the G protein-mediated transduction of odorant signals, providing an indirect inhibition of the olfactory receptor and the perception of smell. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
α-Pinene acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway linked to Or1e35. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
1-Octen-3-ol | 3391-86-4 | sc-237604 | 25 g | $49.00 | ||
1-Octen-3-ol functions as a direct inhibitor by disrupting the 7-transmembrane domain structure of Or1e35. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||