Olfr346 Inhibitors
Inhibitors of Olfr346 achieve their effect by engaging the receptor's ligand-binding domain, which is instrumental in recognizing specific scent molecules. Molecules like certain aldehydes compete by attaching themselves to this domain, thereby preventing the receptor from interacting with its intended ligands, which diminishes the strength of olfactory signaling. Compounds within the terpene family, as well as monoterpenoid alcohols, similarly obstruct the receptor's ability to detect its natural ligands, which is essential for the conversion of olfactory stimuli into neural signals. These molecules act as competitive inhibitors, resembling the natural ligands' structure and vying for occupancy of the same site on Olfr346, which hampers the receptor's ability to detect odors.
Additional inhibitors, including various esters and synthetic derivatives, follow a comparable route, by binding to the receptor's active site and blocking the natural ligands' access, which impedes the initiation of the olfactory signaling process. Aromatic ethers and certain synthetic aldehydes share this inhibitory tactic, latching onto Olfr346 and leading to a reduction in the receptor's activation, hence dampening the olfactory signal transmission.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol binds competitively to the ligand-binding domain of Olfr346, preventing its natural agonists from activating the receptor and thereby reducing its olfactory signaling function. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
This ester functions as a competitive antagonist to Olfr346 by occupying its active site, which impairs the receptor's capacity to recognize and respond to odorant molecules, leading to inhibited olfactory signaling. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal is an aldehyde that can bind to the ligand-binding site of Olfr346, acting as an inhibitor by blocking the receptor's ability to interact with its natural ligands, thus diminishing olfactory signal transduction. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
As an ester with a fragrance, may act as a competitive ligand to Olfr346, inhibiting its normal function by binding to the same site as the receptor's natural ligand, therefore decreasing the receptor's signaling activity. | ||||||
Anisole | 100-66-3 | sc-233877 sc-233877A | 500 ml 2.5 L | $65.00 $204.00 | ||
An aromatic ether that can inhibit Olfr346 by binding to its olfactory receptor site, thus preventing the interaction with its natural agonists and reducing olfactory signaling. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
This synthetic compound acts as an antagonist to Olfr346 by binding to the same site as the natural ligands, effectively blocking the receptor's ability to detect its specific odorants, thereby inhibiting the olfactory signaling pathway. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene, a common terpene, binds to the active site of Olfr346, preventing the natural ligand-receptor interactions and leading to a reduction in the receptor's signaling function. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
Alpha-ionone competes with the natural ligands of Olfr346 for binding to its active site, which inhibits the receptor's signaling capabilities by preventing the normal ligand-receptor interaction necessary for olfactory transduction. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
This aldehyde inhibits Olfr346 by binding to the receptor's ligand-binding site, thereby obstructing the interaction with its natural odorant ligands and diminishing the olfactory signaling pathway mediated by the receptor. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
As a monoterpenoid alcohol, geraniol serves as an inhibitor to Olfr346 by binding to its ligand-binding domain, blocking the natural ligand from activating the receptor and thus reducing its function in olfactory signaling. | ||||||