Olfr323 Inhibitors
Inhibitors of Olfr323 operate by engaging with the intricate network of signaling pathways within olfactory sensory neurons. These inhibitors exert their effects by binding to receptor sites or modulating the activity of channels and proteins that influence the sensory neuron signaling cascade. For instance, compounds that act as agonists for the transient receptor potential (TRP) channels, such as those eliciting thermal sensations, can indirectly inhibit Olfr323. The activation of TRP channels like TRPM8 or TRPV1 by these chemicals results in depolarization and an influx of ions, which can overshadow and suppress the normal signaling of olfactory receptors, including Olfr323. Other inhibitors work by binding to odorant receptors with a higher affinity than the natural ligands of Olfr323, creating competitive or allosteric interactions that impede the receptor's ability to detect odorous molecules. This blockade of the olfactory signaling pathway ensures that the activity of Olfr323 is reduced, as the receptor's normal function is contingent on its ability to bind specific odorants.
Furthermore, some inhibitors may affect the availability of ligands for Olfr323 by binding to odorant-binding proteins or by activating related olfactory receptors, leading to a form of indirect inhibition. For example, α-Ionone's capacity to bind and activate certain olfactory receptors can result in competitive inhibition or alter the signaling crosstalk within olfactory sensory neurons, thereby dampening Olfr323's activity. Additionally, compounds like methyl salicylate might engage with G-protein coupled receptors in the olfactory neurons, leading to an inhibition of Olfr323 through competitive binding or by disrupting intracellular signaling pathways that are crucial for the receptor's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
Agonist of transient receptor potential (TRP) channels, particularly TRPM8. Olfr323, being an olfactory receptor, could be indirectly inhibited by the altered sensory neuron signaling resulting from TRPM8 activation, which may override olfactory signaling pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Activates TRPV1 channels, leading to sensory neuron depolarization. This activity could suppress the signaling of olfactory receptors like Olfr323 by overriding the neuron's response to olfactory cues. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $40.00 | 2 | |
Known TRPM8 agonist that triggers a cooling sensation by modulating sensory neuron activity, potentially diminishing the functional signaling of olfactory receptors like Olfr323 by altering neuron response patterns. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Agonist for TRPV1 and TRPM8 channels in sensory neurons. It can indirectly inhibit Olfr323 by initiating TRP channel-mediated neuronal responses, which may compete with olfactory receptor signaling. | ||||||
Diethyl phthalate | 84-66-2 | sc-239738 sc-239738A | 25 ml 500 ml | $26.00 $32.00 | ||
Affects olfactory receptor function by binding to odorant-binding proteins, possibly leading to reduced activity of receptors like Olfr323 due to altered ligand availability. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
Can bind to and activate certain olfactory receptors, potentially causing an inhibitory effect on Olfr323 through competitive binding or downstream signaling crosstalk in olfactory sensory neurons. | ||||||
Cadaverine | 462-94-2 | sc-239454 | 10 ml | $212.00 | ||
Binds to and activates trace amine-associated receptors (TAARs) in the olfactory system, which could indirectly inhibit Olfr323 activity by modulating intracellular signaling pathways and neuronal response. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Activates TRPA1 channels in sensory neurons, potentially leading to an inhibition of other sensory receptors like Olfr323 due to the neuron's altered signaling state. | ||||||
2-Nonanone | 821-55-6 | sc-238184 sc-238184A | 5 g 100 g | $46.00 $82.00 | ||
Known to interact with olfactory receptors, and it may inhibit Olfr323 by competitive binding or by influencing receptor conformation and function. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Commonly recognized by olfactory receptors; could antagonize Olfr323 function by binding to the same or nearby receptors, altering the receptor environment and signaling. | ||||||