Olfr1002 Activators
Activators of the mouse Olfr1002 are essentially odorant chemicals capable of binding to the olfactory receptor's ligand-binding domain, which initiates a G-protein-coupled receptor (GPCR) signaling cascade. Upon ligand binding, the receptor undergoes a conformational change that activates the associated G-protein by exchanging GDP for GTP on the alpha subunit. This, in turn, leads to the activation of adenylate cyclase, increasing the concentration of cAMP, which opens cyclic nucleotide-gated ion channels leading to an influx of calcium andsodium ions that result in depolarization and the initiation of an action potential in olfactory sensory neurons. The specific chemicals listed are structurally similar to known odorants, and although not proven, they have the potential to interact with and activate olfactory receptors due to their chemical properties like functional groups and molecular shape.
The chemical class that may act as activators for Olfr1002 is diverse, ranging from phenolic compounds like eugenol to terpenoids such as limonene and linalool. Each molecule's ability to activate the receptor is predicated on its interaction with specific regions within the receptor's binding pocket, which may have preferences for certain molecular features like hydrogen bonding, hydrophobic interactions, and steric complementarity. The direct binding of these odorant molecules to Olfr1002 is essential for the subsequent signaling events, ensuring the specificity of the olfactory response. The variety of activators reflects the broad spectrum of chemical structures that olfactory receptors are capable of sensing, which is crucial for the discrimination of a wide array of odors in the environment. The commonality among these diverse chemicals is their capacity to elicit a conformational change in the receptor, which is a crucial first step in the sensory perception of odors. This group of chemicals, despite their differences, shares the functional mechanism of GPCR activation through ligand binding, illustrating the universal nature of olfactory signal transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol is a phenolic compound present in essential oils like clove oil. It binds to certain olfactory receptors, initiating a G-protein-coupled receptor signaling cascade that leads to the activation of olfactory sensory neurons, potentially including those expressing Olfr1002. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a key component of lemongrass oil, is an aldehyde that can activate some olfactory receptors by binding to their ligand-binding domain, which might include Olfr1002, leading to the activation of sensory neurons. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate, known for its banana-like odor, is an ester that could potentially activate Olfr1002 by interacting with the receptor's binding site and triggering the olfactory signal transduction pathway. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a monoterpenoid and an alcohol, is found in rose oil and citronella. Its interaction with olfactory receptors can elicit a signaling response that may include activation of Olfr1002. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, the primary component of vanilla bean extract, is an aromatic aldehyde. It may activate certain olfactory receptors, potentially including Olfr1002, by binding to their active sites. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $28.00 | 1 | |
Anethole is an aromatic compound that has a sweet, licorice-like odor and may activate some olfactory receptors, such as Olfr1002, by binding to them and inducing a signaling cascade. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene, a prominent component of citrus peel oil, is a monoterpene that might interact with olfactory receptors including Olfr1002, causing activation of their signaling pathways. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, commonly known as wintergreen oil, is an ester that could bind to and activate olfactory receptors, potentially including Olfr1002. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal, an aldehyde with a grassy aroma, may interact with olfactory receptors such as Olfr1002 and induce activation of their associated sensory neurons. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, a naturally occurring terpene alcohol found in many flowers and spice plants, may activate olfactory receptors including Olfr1002 by binding to their specific sites. | ||||||