OGFOD1 Activators
OGFOD1, or 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, is a protein encoded by the OGFOD1 gene in humans. This protein belongs to the 2OG-Fe(II) oxygenase superfamily, which is characterized by a double-stranded beta-helix (DSBH) core structure and a conserved iron-binding motif.OGFOD1 has a role in post-transcriptional modification and is known to hydroxylate a specific proline residue (Pro-38) in the small ribosomal subunit protein uS12. This modification is speculated to function in optimizing the conformation of the anticodon stem-loop of the tRNA during the decoding of the genetic code.
Additionally, alterations in OGFOD1 expression have been implicated in tumorigenesis, due to the protein's role in the regulation of hypoxia-inducible factor (HIF), a transcription factor that plays a crucial role in cellular responses to low oxygen conditions.In summary, as a prolyl hydroxylase, OGFOD1 plays a crucial role in the proper functioning of the ribosome and in protein synthesis. It is also implicated in the regulation of cellular responses to hypoxia, making it a protein of interest in the study of cancer biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
As a co-substrate for OGFOD1, increased levels of 2OG could enhance its enzymatic activity. | ||||||
Iron | 7439-89-6 | sc-215190 sc-215190A | 500 g 2 kg | $69.00 $180.00 | ||
Essential for the catalytic activity of OGFOD1, iron supplementation could support its function. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Can enhance the activity of 2OG-dependent dioxygenases by maintaining iron in a reduced state. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
As an intermediate of the TCA cycle, it may indirectly influence OGFOD1 activity through cellular metabolic pathways. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $43.00 $57.00 $114.00 $228.00 | ||
Another TCA cycle intermediate, potentially influencing the metabolic context of OGFOD1. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
As a substrate for nitric oxide synthase, it might indirectly influence cellular oxygen sensing mechanisms involving OGFOD1. | ||||||