OBCAM Activators
OPCML Activators refer to substances that can modulate the activity of the OPCML protein. Most of these are substances that affect cell adhesion processes, either by influencing cyclic nucleotide levels or by affecting cytoskeletal dynamics. Forskolin, IBMX, and rolipram are examples of the former. They affect adenylyl cyclase or phosphodiesterases, enzymes involved in the metabolism of cyclic AMP, a second messenger involved in numerous cellular processes including cell adhesion. By increasing cyclic AMP levels, these substances can indirectly influence OPCML, which is involved in cell adhesion processes.
On the other hand, vincristine, paclitaxel, cytochalasin D, jasplakinolide, blebbistatin, Y-27632, SB431542, PD98059, and U0126 are substances that affect cytoskeletal dynamics or related signaling pathways. Vincristine and paclitaxel affect microtubules, while cytochalasin D and jasplakinolide affect actin polymerization. Blebbistatin inhibits non-muscle myosin II ATPase, and Y-27632 inhibits Rho-associated protein kinase (ROCK), both of which are involved in cytoskeletal dynamics. SB431542, PD98059, and U0126 inhibit signaling pathways that can affect cell adhesion processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylyl cyclase, which increases the levels of cyclic AMP in cells. This can indirectly affect OPCML as cyclic AMP is a second messenger in numerous cellular processes including cell adhesion. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, enzymes that break down cyclic AMP and cyclic GMP. By inhibiting these enzymes, IBMX can increase the levels of these cyclic nucleotides, indirectly influencing OPCML. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A selective inhibitor of phosphodiesterase-4, an enzyme that degrades cyclic AMP. By increasing cyclic AMP levels, it can indirectly influence OPCML. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
A microtubule-stabilizing agent that can affect cell adhesion processes and thus indirectly influence OPCML. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An actin polymerization inhibitor that can affect cell adhesion processes and thus indirectly influence OPCML. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
An actin polymerization inducer that can affect cell adhesion processes and thus indirectly influence OPCML. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
An inhibitor of non-muscle myosin II ATPase, which can affect cell adhesion processes and thus indirectly influence OPCML. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
An inhibitor of Rho-associated protein kinase (ROCK), which can affect cell adhesion processes and thus indirectly influence OPCML. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
An inhibitor of the transforming growth factor-beta (TGF-β) type I receptor ALK5, which can affect cell adhesion processes and thus indirectly influence OPCML. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of the MAPK/ERK pathway, which can affect cell adhesion processes and thus indirectly influence OPCML. | ||||||