OATP-J Activators
OATP-J, formally known as Organic Anion Transporting Polypeptide J (OATP1B3), is a membrane transport protein encoded by the SLCO1B3 gene in humans. As a member of the OATP family, OATP-J plays a critical role in the hepatic uptake of a wide array of endogenous and exogenous organic anions, including bile acids, bilirubin, hormones, drugs, and toxins.This transporter is predominantly expressed in the liver on the basolateral (sinusoidal) membrane of hepatocytes. OATP-J functions by mediating the sodium-independent transport of its substrates from the blood into the liver cells, a process that is essential for the subsequent metabolism and excretion of these compounds. This uptake mechanism is a key step in the detoxification and clearance pathways that safeguard the body from potentially harmful substances.
OATP1B3 operates via an exchange mechanism, often coupling the cellular uptake of one compound with the efflux of another. This bidirectional transport is important for maintaining the homeostasis of various molecules within the body. OATP-J's ability to interact with a diverse range of substrates highlights its significance in pharmacokinetics, as it can influence the distribution, metabolism, and elimination of numerous drugs. Variations in the SLCO1B3 gene can affect the function and expression of OATP-J, leading to interindividual differences in drug response and disposition. Polymorphisms in this gene have been linked to altered pharmacokinetics of certain drugs and may contribute to the susceptibility to drug-induced liver injury or other adverse drug reactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
An antibiotic known to induce certain OATP transporters, potentially affecting their activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
An immunosuppressant that inhibits various OATP transporters, affecting their function. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
An antibiotic that can inhibit OATP transporters, affecting drug and bile acid transport. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
A statin that is a substrate for OATP transporters, potentially affected by OATP modulation. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
A compound from milk thistle that can modulate OATP transporter activity. | ||||||
Indinavir | 150378-17-9 | sc-353630 | 100 mg | $982.00 | 1 | |
An HIV protease inhibitor known to interact with OATP transporters. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
An inhibitor of various transporters, including some OATPs, affecting drug excretion. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $145.00 | 8 | |
A statin that is a substrate for OATP transporters, potentially affected by their modulation. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
An antifungal agent that can inhibit OATP transporters, affecting drug transport. | ||||||