Nurr1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin is an indirect inhibitor of Nurr1. It activates AMP-activated protein kinase (AMPK), which can inhibit Nurr1 indirectly. AMPK activation by metformin influences cellular energy homeostasis, leading to downstream effects that modulate Nurr1 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, an indirect inhibitor of Nurr1, activates Sirtuin 1 (SIRT1). SIRT1, a NAD+-dependent deacetylase, can deacetylate and modulate Nurr1 function. Resveratrol's influence on SIRT1 activity can lead to changes in Nurr1 acetylation and subsequent modulation of its transcriptional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, an indirect inhibitor of Nurr1, can modulate Nurr1 activity through various pathways. It influences multiple signaling cascades, including the nuclear factor-kappa B (NF-κB) pathway, which is interconnected with Nurr1 function. Curcumin's impact on NF-κB and other pathways can lead to indirect modulation of Nurr1 transcriptional activity and downstream effects. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium, an indirect inhibitor of Nurr1, can modulate Nurr1 activity through the glycogen synthase kinase-3 beta (GSK-3β) pathway. Lithium inhibits GSK-3β, affecting downstream signaling pathways that intersect with Nurr1. The intricate crosstalk between lithium's action on GSK-3β and Nurr1 provides a mechanism for indirect modulation of Nurr1 function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Butyrate, a short-chain fatty acid, indirectly influences Nurr1 by acting as a histone deacetylase (HDAC) inhibitor. Butyrate inhibits HDACs, altering chromatin structure and influencing gene expression, including genes regulated by Nurr1. The indirect modulation of Nurr1 by butyrate occurs through epigenetic mechanisms that impact the acetylation status of histones associated with Nurr1 target genes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, an indirect inhibitor of Nurr1, activates the nuclear factor erythroid 2-related factor 2 (NRF2) pathway. NRF2 activation by sulforaphane influences cellular responses and may intersect with Nurr1 pathways. The indirect modulation of Nurr1 occurs through NRF2-mediated effects on cellular redox balance and gene expression, contributing to the overall regulatory network governing Nurr1 activity. | ||||||
GSK-J4 Hydrochloride | 1797983-09-5 | sc-490344 | 5 mg | $260.00 | 1 | |
GSK-J4 is an indirect inhibitor of Nurr1 that targets histone lysine demethylase 6B (KDM6B). By inhibiting KDM6B, GSK-J4 influences histone methylation patterns associated with Nurr1 target genes. This epigenetic modulation can result in changes in Nurr1 transcriptional activity and downstream effects on gene expression. The intricate interplay between GSK-J4, KDM6B, and Nurr1 provides a unique avenue for indirect modulation of Nurr1 function. | ||||||