Nup98 Activators

The chemical class known as Nup98 Activators comprises a diverse group of compounds that exert their influence on the nucleoporin Nup98 through various signaling pathways and cellular processes. Retinoic acid activates the retinoic acid receptor (RAR) signaling pathway, indirectly impacting Nup98 expression by influencing the transcriptional regulation of genes related to nucleocytoplasmic transport. Forskolin, a potent adenylate cyclase activator, elevates cAMP levels, modulating the PKA pathway and affecting cellular processes associated with nucleocytoplasmic transport, providing an indirect avenue for Nup98 modulation. Lithium chloride, through activation of the Wnt/β-catenin pathway, indirectly influences Nup98 by altering the canonical Wnt signaling cascade, impacting nucleocytoplasmic transport processes.

Epigallocatechin gallate (EGCG), a polyphenol, activates AMP-activated protein kinase (AMPK), indirectly affecting Nup98 by regulating cellular energy status and processes related to nucleocytoplasmic transport through downstream signaling events. These compounds collectively exemplify the intricate web of interactions that define the Nup98 Activators, demonstrating their ability to modulate nucleocytoplasmic transport processes through diverse biochemical and cellular pathways.