NTF2 Inhibitors

The chemical inhibitors listed above are primarily compounds that modulate various aspects of nuclear transport and cellular transport mechanisms. Since NTF2 is involved in the nuclear import of Ran, influencing these pathways can indirectly affect NTF2's role and function. Leptomycin B and KPT-330 (Selinexor) are inhibitors of CRM1/exportin 1, a key protein in the nuclear export pathway. By inhibiting nuclear export, these compounds can create an imbalance in nuclear transport, potentially impacting NTF2's role in nuclear import. Importazole, a specific inhibitor of the importin β/Ran-GTP complex, directly impacts the nuclear import pathway. Though not targeting NTF2 directly, altering the importin β/Ran-GTP dynamics can indirectly affect the function of NTF2.

Ivermectin, an antiparasitic agent, has been shown to affect nuclear transport processes. Its role in influencing these mechanisms may extend to impacting NTF2 function. Agents like WGA (Wheat Germ Agglutinin), which inhibit the nuclear pore complex, can also indirectly affect NTF2 by altering the overall nucleocytoplasmic transport. Brefeldin A disrupts the Golgi apparatus, and other compounds like Ranolazine, Bisindolylmaleimide I, Colchicine, Paclitaxel, and Nocodazole affect various aspects of cellular transport and cytoskeletal dynamics. These changes can influence the cellular transport environment in which NTF2 operates. MLN8237, an inhibitor of Aurora A kinase, affects mitotic processes and could have indirect implications on NTF2's function during cell division.