Date published: 2026-5-30

1-800-457-3801

SCBT Portrait Logo
Seach Input

NT-3 Inhibitors

NT-3 inhibitors constitute a diverse array of chemicals designed to modulate the signaling pathways associated with Neurotrophin-3 (NT-3). These chemicals can be broadly categorized into two groups: direct Trk receptor inhibitors and indirect pathway modulators. The direct inhibitors, such as K252a, GW441756, K252b, and Ro 08-2750, exert their effects by interfering with NT-3 signaling at the level of Trk receptors. These compounds act as antagonists, effectively blocking the Trk receptors and impeding the downstream cascades that are integral to NT-3-mediated cellular responses. The disruption of signaling pathways, including MAPK and PI3K, plays a pivotal role in attenuating the cellular effects induced by NT-3. K252a, a well-known Trk receptor inhibitor, competes with neurotrophins for binding to Trk receptors, thereby inhibiting NT-3 signaling. Similarly, GW441756, K252b, and Ro 08-2750 act as selective inhibitors of Trk receptors, contributing to the specificity of their action in modulating NT-3 responses. The second group of NT-3 inhibitors comprises indirect modulators that target pathways interconnected with NT-3 signaling. LY294002 and Wortmannin, for instance, are potent inhibitors of the PI3K pathway, an essential component in the NT-3 signaling cascade. By blocking PI3K, these chemicals disrupt downstream events crucial for NT-3-mediated cellular responses. Additionally, U0126 and SB 203580 function as indirect inhibitors by specifically targeting the MAPK pathway associated with NT-3 signaling. This dualistic approach of inhibiting both Trk receptors and interconnected pathways highlights the intricacies of NT-3 signaling regulation. Furthermore, SU 5402 and SU 6668 exert their effects by modulating the cross-talk between FGFR and Trk receptors, further underscoring the complexity of signaling networks involved in NT-3 responses.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

K-252a

99533-80-9sc-200517
sc-200517B
sc-200517A
100 µg
500 µg
1 mg
$129.00
$214.00
$498.00
19
(2)

K252a is a selective Trk receptor inhibitor that indirectly modulates NT-3 signaling. By inhibiting Trk receptors, K252a interferes with the downstream activation of pathways, such as MAPK and PI3K, which are crucial for NT-3-mediated cellular responses, providing an indirect means to influence NT-3 signaling and downstream effects.

GW-441756

504433-23-2sc-200683
sc-200683A
10 mg
50 mg
$141.00
$565.00
3
(1)

GW441756 is a small-molecule Trk receptor inhibitor that disrupts NT-3 signaling. By specifically targeting Trk receptors, GW441756 hinders the activation of downstream signaling cascades, including MAPK and PI3K pathways, resulting in the inhibition of NT-3-mediated cellular responses and providing a direct means to modulate NT-3 function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a potent inhibitor of PI3K, a downstream effector in the NT-3 signaling pathway. By blocking PI3K activity, LY294002 disrupts the intracellular signaling initiated by NT-3 binding to its receptors, leading to the inhibition of NT-3-mediated cellular processes. This compound offers a direct means to interfere with NT-3 signaling through the PI3K pathway.

K-252b

99570-78-2sc-200585
sc-200585A
100 µg
1 mg
$184.00
$612.00
1
(1)

K252b, similar to K252a, is a Trk receptor inhibitor that indirectly modulates NT-3 signaling. By targeting Trk receptors, K252b disrupts the downstream activation of pathways essential for NT-3-mediated cellular responses. This indirect inhibition highlights K252b as a compound capable of influencing NT-3 signaling through the modulation of Trk receptor activity.

Ro 08-2750

37854-59-4sc-203682
sc-203682A
1 mg
10 mg
$188.00
$416.00
1
(0)

Ro 08-2750 is a selective Trk receptor inhibitor that directly influences NT-3 signaling. By inhibiting Trk receptors, Ro 08-2750 specifically disrupts the downstream signaling pathways activated by NT-3, providing a direct means to modulate NT-3-mediated cellular responses. This compound offers targeted inhibition of NT-3 signaling through Trk receptors.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is a MEK1/2 inhibitor that indirectly influences NT-3 signaling through the MAPK pathway. By blocking MEK1/2, U0126 disrupts the downstream activation of MAPK, a pathway critical for NT-3-mediated cellular responses. This indirect inhibition positions U0126 as a compound capable of modulating NT-3 signaling through interference with the MAPK pathway.

SU 5402

215543-92-3sc-204308
sc-204308A
1 mg
5 mg
$63.00
$98.00
36
(3)

SU 5402 is a fibroblast growth factor receptor (FGFR) inhibitor that indirectly affects NT-3 signaling. By targeting FGFR, SU 5402 disrupts cross-talk between FGFR and Trk receptors, leading to an indirect inhibition of NT-3-mediated cellular responses. This compound highlights the interconnectedness of signaling pathways and provides an indirect means to influence NT-3 signaling through FGFR inhibition.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a non-specific PI3K inhibitor that directly modulates NT-3 signaling through the PI3K pathway. By inhibiting PI3K, Wortmannin disrupts the intracellular signaling initiated by NT-3 binding to its receptors, providing a direct means to interfere with NT-3-mediated cellular processes. This compound offers targeted inhibition of NT-3 signaling through the PI3K pathway.

Tyrphostin AG 879

148741-30-4sc-3557
sc-3557A
5 mg
25 mg
$83.00
$328.00
4
(1)

AG 879 is a selective ErbB2 inhibitor that indirectly influences NT-3 signaling. By targeting ErbB2, AG 879 disrupts cross-talk between ErbB2 and Trk receptors, leading to an indirect inhibition of NT-3-mediated cellular responses. This compound highlights the interconnectedness of signaling pathways and provides an indirect means to modulate NT-3 signaling through ErbB2 inhibition.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD 98059 is a selective MEK1 inhibitor that indirectly modulates NT-3 signaling through the MAPK pathway. By inhibiting MEK1, PD 98059 disrupts the downstream activation of MAPK, a pathway crucial for NT-3-mediated cellular responses. This indirect inhibition positions PD 98059 as a compound capable of modulating NT-3 signaling through interference with the MAPK pathway.