NSUN4 Activators
NSUN4 is a member of the NOP2/Sun domain family, and it plays a crucial role in the biogenesis of mitochondrial ribosomes. As a methyltransferase, NSUN4 specifically targets the mitochondrial 12S rRNA and is essential for the assembly of the small ribosomal subunit. Moreover, NSUN4 is involved in the maintenance of mitochondrial DNA and overall mitochondrial health. The precise expression levels of NSUN4 are fundamental for the proper function of mitochondria, which are the cell's powerhouse, responsible for producing energy in the form of ATP. As such, the regulation of NSUN4 is of interest in studies focusing on mitochondrial dynamism and the cellular energy balance. Research exploring the induction of NSUN4 expression has the potential to shed light on the intricate web of genetic regulation that orchestrates mitochondrial function and efficiency.
Exploring the molecular inducers of NSUN4 expression, researchers have identified a range of chemicals that could potentially serve as activators. Compounds like retinoic acid and forskolin are known to stimulate gene expression related to mitochondrial function by engaging with cellular signaling pathways. For instance, retinoic acid, through its interaction with nuclear receptors, can initiate transcriptional programs that may include genes like NSUN4. Forskolin, by increasing cAMP levels, potentially activates protein kinase A, which can phosphorylate transcription factors and promote the expression of genes involved in mitochondrial biogenesis, including NSUN4. Other molecules, such as 5-Azacytidine and Trichostatin A, can alter epigenetic markers-5-Azacytidine by reducing DNA methylation and Trichostatin A by inhibiting histone deacetylases-leading to a more transcriptionally active chromatin state at the NSUN4 locus. Substances such as Sodium Butyrate and Resveratrol also play roles in the modification of histones, which can result in the upregulation of NSUN4. These chemicals, each with unique molecular mechanisms, exemplify the diverse strategies cells might employ to modulate the expression of key genes like NSUN4, which is pivotal for mitochondrial ribosome assembly and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could upregulate NSUN4 by binding to retinoid receptors, leading to the activation of gene transcription programs that include mitochondrial ribosome assembly factors. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could stimulate NSUN4 transcription through the hypomethylation of its gene promoter, thereby enhancing RNA polymerase II binding and activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may increase NSUN4 expression by raising intracellular cAMP levels, leading to the activation of protein kinase A (PKA) and subsequent phosphorylation of transcription factors that govern mitochondrial gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A could stimulate NSUN4 expression by inhibiting histone deacetylases, causing an open chromatin state at the NSUN4 locus and facilitating transcriptional activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate may induce NSUN4 through hyperacetylation of histones near the gene, enhancing the accessibility of the chromatin to transcription machinery. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could stimulate the expression of NSUN4 by activating SIRT1, leading to deacetylation of transcription factors or coactivators involved in mitochondrial gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This compound might upregulate NSUN4 by altering the DNA methylation patterns and histone modifications at the gene locus, leading to enhanced transcriptional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may upregulate NSUN4 by activating transcription factors such as NF-κB, which can then bind to specific elements in the promoter region of genes related to mitochondrial function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane could induce the expression of NSUN4 by stimulating the Nrf2 pathway, which drives the transcription of genes involved in cellular defense against oxidative stress, potentially including mitochondrial ribosome assembly components. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin may upregulate NSUN4 by activating AMP-activated protein kinase (AMPK), which is known to stimulate mitochondrial biogenesis and could enhance the transcription of related genes. | ||||||