NSP3 Activators
NSP3 Activators are a group of chemicals that can enhance the functional activity of NSP3 by primarily inhibiting the activity of various kinases that are known to downregulate NSP3. These kinases include protein kinase C (PKC), phosphoinositide 3-kinases (PI3K), MEK1/2, Src family kinases, JNK, Rho-associated protein kinases (ROCK), EGFR tyrosine kinase, and mTOR. By inhibiting these kinases, the NSP3 Activators can prevent kinase-dependent phosphorylation and subsequent downregulation of NSP3, leading to an enhanced functional activity of NSP3.
The NSP3 Activators include Bisindolylmaleimide I, LY294002, PD98059, Staurosporine, U0126, Wortmannin, PP2, SP600125, Y-27632, AG1478, SU6656, andRapamycin. These chemicals disrupt the kinase-dependent signaling pathways, thereby preventing the downregulation of NSP3. For instance, Bisindolylmaleimide I and Staurosporine inhibit PKC to prevent PKC-dependent phosphorylation of NSP3. LY294002 and Wortmannin, on the other hand, inhibit PI3K to disrupt PI3K-dependent signaling events that lead to NSP3 downregulation. PD98059 and U0126 inhibit MEK1/2 to attenuate the ERK signaling pathway, which is associated with the downregulation of NSP3. Similarly, PP2 and SU6656 inhibit Src family kinases to disrupt Src-dependent signaling pathways, while SP600125 inhibits JNK to disrupt JNK-dependent signaling pathways. Y-27632 inhibits ROCK to disrupt ROCK-dependent pathways, AG1478 inhibits EGFR to disrupt EGFR-dependent pathways, and Rapamycin inhibits mTOR to disrupt mTOR-dependent pathways. By disrupting these pathways, the NSP3 Activators enhance the functional activity of NSP3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a potent and selective inhibitor of protein kinase C (PKC). By inhibiting PKC, it can enhance NSP3 activity by preventing PKC-dependent phosphorylation and subsequent downregulation of NSP3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it can enhance NSP3 activity by disrupting PI3K-dependent signaling events that lead to NSP3 downregulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK1/2. The inhibition of MEK can attenuate ERK signaling pathway, which has been associated with the downregulation of NSP3. Therefore, PD98059 can enhance the activity of NSP3. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. By inhibiting PKC, it can enhance NSP3 activity by preventing PKC-dependent phosphorylation and subsequent downregulation of NSP3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By inhibiting PI3K, it can enhance NSP3 activity by disrupting PI3K-dependent signaling events that lead to NSP3 downregulation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family kinases. By inhibiting Src kinases, it can enhance NSP3 activity by disrupting Src-dependent signaling pathways that lead to NSP3 downregulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK. By inhibiting JNK, it can enhance NSP3 activity by disrupting JNK-dependent signaling pathways that lead to NSP3 downregulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinases (ROCK). By inhibiting ROCK, it can enhance NSP3 activity by disrupting ROCK-dependent signaling pathways that lead to NSP3 downregulation. | ||||||
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $94.00 $413.00 | 16 | |
AG1478 is a selective inhibitor of EGFR tyrosine kinase. By inhibiting EGFR, it can enhance NSP3 activity by disrupting EGFR-dependent signaling pathways that lead to NSP3 downregulation. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $56.00 $130.00 | 27 | |
SU6656 is a selective inhibitor of Src family kinases. By inhibiting Src kinases, it can enhance NSP3 activity by disrupting Src-dependent signaling pathways that lead to NSP3 downregulation. | ||||||