NSE1 Activators

The chemical class of NSE1 Activators includes compounds that can indirectly influence NSE1 function through their effects on DNA replication stress, DNA damage response, and DNA repair pathways. NSE1, as part of the SMC5/SMC6 complex, plays a significant role in maintaining genomic stability and responding to DNA damage. Compounds such as Hydroxyurea, Mitomycin C, Cisplatin, Etoposide, Doxorubicin, and Camptothecin can induce DNA damage or replication stress, potentially impacting NSE1 activity. The response to DNA damage and replication stress often involves activation of DNA repair mechanisms, in which NSE1 plays a crucial role.

Other agents that affect DNA synthesis and repair, such as Aphidicolin, Bleomycin, 5-Fluorouracil, Gemcitabine, and Olaparib, could also indirectly influence NSE1. These compounds can lead to situations where DNA repair is necessary, potentially involving the SMC5/SMC6 complex and NSE1.Furthermore, inhibitors of DNA damage response kinases like ATR inhibitors can modulate the cellular response to DNA damage and replication stress, potentially affecting NSE1 activity.