NSD2 Activators

The chemical class of NSD2 Activators includes compounds that can indirectly influence NSD2 function through their effects on chromatin remodeling, gene expression, and cellular stress responses. NSD2, as a histone methyltransferase, plays a critical role in modulating chromatin structure and gene expression regulation. HDAC inhibitors such as Trichostatin A, Valproic Acid, Sodium Butyrate, Vorinostat, and others, by altering chromatin dynamics and gene expression patterns, can potentially modulate NSD2 activity. These inhibitors affect chromatin structure, which is crucial for the regulation of proteins involved in chromatin remodeling, including NSD2.

Compounds that influence gene expression and cellular differentiation, such as Retinoic Acid and Genistein, might modulate the expression of genes regulated by or coding for NSD2, thereby influencing its function. Additionally, natural compounds with various biological activities like Curcumin, Resveratrol, EGCG, and Sulforaphane can influence cellular signaling pathways and stress responses, potentially modulating NSD2 activity. Furthermore, Lithium Chloride, a GSK-3 inhibitor, by impacting key cellular signaling pathways, can have downstream effects on NSD2 function. Modulating these signaling pathways could indirectly affect the activity of NSD2 in the context of chromatin remodeling and gene regulation.