NPY inhibitors, short for Neuropeptide Y inhibitors, belong to a class of chemical compounds that play a crucial role in modulating the activity of the neuropeptide Y (NPY) system within the human body. Neuropeptide Y is a peptide neurotransmitter found in the central and peripheral nervous systems, where it regulates various physiological functions. NPY is known for its involvement in the control of appetite, energy balance, and stress response. As such, NPY inhibitors are substances designed to interfere with the signaling pathways associated with NPY, which can have significant physiological consequences.
The chemical structures of NPY inhibitors can vary widely, but they typically work by binding to NPY receptors or enzymes involved in NPY synthesis and degradation. By doing so, these inhibitors can modulate the release and activity of NPY, thereby influencing processes such as food intake, blood pressure, and stress responses. Researchers have been particularly interested in NPY inhibitors due to their implications in understanding and addressing conditions related to appetite regulation and stress management. The development and study of NPY inhibitors have provided valuable insights into the complex interplay between neuropeptides and neural signaling, shedding light on the underlying mechanisms of conditions like obesity, anxiety, and hypertension.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BIIE 0246 | 246146-55-4 | sc-203530 sc-203530A | 1 mg 10 mg | $321.00 $530.00 | 1 | |
BIIE 0246 is a selective NPY Y2 receptor antagonist that hinders NPY binding and signaling through Y2 receptors, leading to reduced food intake and modulation of circadian rhythms. | ||||||
YIL 781 | 875258-85-8 | sc-361410 sc-361410A | 10 mg 50 mg | $179.00 $825.00 | ||
YIL 781 is a non-peptide NPY Y5 receptor antagonist that disrupts NPY signaling at Y5 receptors, leading to decreased food intake and potential therapeutic applications in obesity. | ||||||
JNJ7777120 | 459168-41-3 | sc-252930 | 5 mg | $121.00 | 1 | |
JNJ-7777120 is a selective NPY Y4 receptor antagonist that disrupts NPY signaling through Y4 receptors, potentially impacting gut function and peptide release. | ||||||