Molecular structure of JNJ7777120, CAS Number: 459168-41-3
JNJ7777120 (CAS 459168-41-3)
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Application:
JNJ7777120 is a Histamine H4 Receptor (H4 histamine receptor) antagonist
CAS Number:
459168-41-3
Purity:
≥98%
Molecular Weight:
277.75
Molecular Formula:
C14H16N3OCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JNJ7777120 is a potent, selective non-imidazole Histamine H4 Receptor (H4 histamine receptor) antagonist. It has been studied for its ability to modulate ion channels and receptors, as well as its potential as an imaging agent. Additionally, it may act to have a variety of biochemical and physiological effects, including anti-inflammatory, anti-cancer, and neuroprotective effects.
JNJ7777120 (CAS 459168-41-3) References
- The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva. | Zampeli, E., et al. 2009. Inflamm Res. 58: 285-91. PMID: 19184344
- Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins. | Rosethorne, EM. and Charlton, SJ. 2011. Mol Pharmacol. 79: 749-57. PMID: 21134907
- Paradoxical stimulatory effects of the 'standard' histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity. | Seifert, R., et al. 2011. Mol Pharmacol. 79: 631-8. PMID: 21266488
- Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R. | Wagner, E., et al. 2011. Bioorg Med Chem Lett. 21: 6274-80. PMID: 21944853
- Strain-dependent effects of the histamine H₄ receptor antagonist JNJ7777120 in a murine model of acute skin inflammation. | Coruzzi, G., et al. 2012. Exp Dermatol. 21: 32-7. PMID: 22151388
- Protection of radiation-induced damage to the hematopoietic system, small intestine and salivary glands in rats by JNJ7777120 compound, a histamine H4 ligand. | Martinel Lamas, DJ., et al. 2013. PLoS One. 8: e69106. PMID: 23922686
- Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. | Rosa, AC., et al. 2014. J Pharmacol Exp Ther. 351: 308-16. PMID: 25185215
- The effect of selective antagonist of H4 receptor JNJ7777120 on nasal symptoms, cough, airway reactivity and inflammation in guinea pigs. | Kovacova-Hanuskova, E., et al. 2015. Respir Physiol Neurobiol. 216: 9-14. PMID: 26003849
- JNJ7777120 Ameliorates Inflammatory and Oxidative Manifestations in a Murine Model of Contact Hypersensitivity via Modulation of TLR and Nrf2 Signaling. | Mohamed, AF., et al. 2018. Inflammation. 41: 378-389. PMID: 29127662
- Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model. | Zhou, P., et al. 2019. Brain Behav Immun. 76: 61-73. PMID: 30408497
- Assessment of DNA repair efficiency in the inbred BTBR T+tf/J autism spectrum disorder mouse model exposed to gamma rays and treated with JNJ7777120. | Al-Mazroua, HA., et al. 2019. Prog Neuropsychopharmacol Biol Psychiatry. 93: 189-196. PMID: 30959085
- The histamine-4 receptor antagonist JNJ7777120 prevents immune abnormalities by inhibiting RORγt/T-bet transcription factor signaling pathways in BTBR T+ Itpr3tf/J mice exposed to gamma rays. | Ahmad, SF., et al. 2019. Mol Immunol. 114: 561-570. PMID: 31522074
- Effects of Several Therapeutic Agents on Mammalian Vestibular Function: Meclizine, Diazepam, and JNJ7777120. | Lee, C. and Jones, TA. 2021. J Assoc Res Otolaryngol. 22: 527-549. PMID: 34009490
- A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression. | Yeni, Y., et al. 2022. J Pers Med. 12: PMID: 35207733
Inhibitor of:
DGAT2L3, DGAT2L4, Histamine, Histamine H4 Receptor, and NPY.Activator of:
Histamine H4 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNJ7777120, 5 mg | sc-252930 | 5 mg | $121.00 |