NMDA Inhibitors
Santa Cruz Biotechnology now offers a broad range of NMDA Inhibitors. Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. NMDA Inhibitors offered by Santa Cruz inhibit NMDA and, in some cases, other neurotransmission and neural development related proteins. View detailed NMDA Inhibitor specifications, including NMDA Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 11 to 20 of 67 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(R)-(+)-HA-966 | 123931-04-4 | sc-361303 | 5 mg | $95.00 | ||
(R)-(+)-HA-966 acts as a selective NMDA receptor antagonist, exhibiting unique stereochemical properties that enhance its binding specificity. Its molecular architecture allows for distinct hydrogen bonding interactions with key amino acid residues, stabilizing the receptor-ligand complex. The compound's kinetic profile reveals a slow dissociation rate, prolonging its inhibitory effects. Furthermore, its lipophilicity influences membrane permeability, impacting its overall bioavailability and receptor modulation dynamics. | ||||||
Gavestinel | 153436-38-5 | sc-361183 sc-361183A | 10 mg 50 mg | $159.00 $650.00 | ||
Gavestinel is characterized by its ability to selectively inhibit NMDA receptor activity through unique conformational dynamics. Its structural features facilitate specific electrostatic interactions with receptor sites, enhancing binding affinity. The compound exhibits a notable allosteric modulation effect, altering receptor kinetics and signaling pathways. Additionally, its solubility properties influence its distribution in biological systems, affecting interaction profiles with various ion channels and neurotransmitter systems. | ||||||
Ifenprodil hemitartrate | 23210-58-4 | sc-203601B sc-203601 sc-203601A | 5 mg 10 mg 50 mg | $39.00 $61.00 $142.00 | ||
An atypical noncompetitive antagonist; it modulates NMDA receptors containing the GluN2B subunit. | ||||||
(-)-MK 801 maleate | 77086-19-2 | sc-361253 sc-361253A | 10 mg 50 mg | $59.00 $265.00 | ||
(-)-MK 801 maleate is a potent NMDA receptor antagonist known for its unique binding characteristics that stabilize the receptor in an inactive conformation. This compound exhibits rapid kinetics, allowing for swift modulation of synaptic transmission. Its distinct stereochemistry enhances selectivity, leading to pronounced effects on calcium ion influx and downstream signaling cascades. The compound's lipophilicity contributes to its ability to traverse cellular membranes, influencing its interaction with neuronal circuits. | ||||||
(−)-Huperzine A | 102518-79-6 | sc-200183 sc-200183A | 1 mg 5 mg | $140.00 $355.00 | 1 | |
(-)-Huperzine A is a selective NMDA receptor modulator that exhibits unique allosteric properties, enhancing receptor sensitivity to glutamate. Its intricate molecular interactions facilitate a nuanced regulation of calcium ion dynamics, impacting synaptic plasticity. The compound's ability to penetrate the blood-brain barrier is attributed to its specific hydrophobic characteristics, allowing it to engage in complex signaling pathways within neural networks. Its stereochemical configuration further contributes to its distinct pharmacodynamics. | ||||||
Haloperidol hydrochloride | 1511-16-6 | sc-203593 | 100 mg | $71.00 | 1 | |
Haloperidol hydrochloride acts as a potent NMDA receptor antagonist, exhibiting unique binding affinity that disrupts glutamate-mediated excitatory neurotransmission. Its molecular structure allows for specific interactions with receptor sites, influencing ion channel kinetics and altering calcium influx. This modulation can lead to significant changes in neuronal excitability and synaptic transmission. Additionally, its solubility properties enhance its distribution in biological systems, facilitating diverse interactions within neural circuits. | ||||||
Agmatine sulfate | 2482-00-0 | sc-202920 sc-202920A | 100 mg 500 mg | $69.00 $178.00 | ||
Interacts with several receptors, including acting as an NMDA antagonist. | ||||||
Synthalin sulfate | 111-23-9 | sc-200476 sc-200476A | 10 mg 50 mg | $300.00 $800.00 | ||
Synthalin sulfate functions as a selective NMDA receptor modulator, characterized by its ability to stabilize receptor conformation and influence ligand binding dynamics. Its unique molecular architecture promotes specific interactions with the receptor's allosteric sites, thereby affecting downstream signaling pathways. The compound exhibits distinct reaction kinetics, allowing for rapid modulation of synaptic plasticity. Furthermore, its solubility profile enhances its bioavailability, enabling intricate interactions within neural networks. | ||||||
Spermine, Tetrahydrochloride | 306-67-2 | sc-202817 | 5 g | $166.00 | ||
Spermine, Tetrahydrochloride acts as a potent NMDA receptor modulator, distinguished by its polyamine structure that facilitates unique electrostatic interactions with receptor sites. This compound influences ion channel permeability and alters calcium influx, crucial for synaptic transmission. Its ability to form stable complexes with receptor subunits enhances receptor sensitivity, while its dynamic binding kinetics allow for nuanced regulation of neuronal excitability and plasticity. | ||||||
1-Adamantylamine | 768-94-5 | sc-251475 sc-251475A | 1 g 25 g | $38.00 $144.00 | ||
While its primary function is antiviral, it acts as a weak noncompetitive NMDA antagonist. | ||||||