Haloperidol hydrochloride is a dopamine inhibitor selective for D2DR (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2DR, D3DR, D4DR, D1DR and D5DR receptors respectively). Haloperidol is a subtype-selective NMDA inhibitor and also acts as a non-competitive inhibitor of NOS1 (nNOS) activity (Ki = 31 μM). Haloperidol hydrochloride is an inhibitor of D2DR, D3DR and D4DR.
1. Beresford, R. and Ward. A. 1987. Drugs 33:31-49. 2. Seeman, P. and Van Tol, H.H. 1994. Trends Pharmacol. Sci. 15: 264-240. 3. Lynch, D.R. and Gallagher, M.J. 1996. J. Pharmacol. Exp. Ther. 279: 154-161. 4. Ilyin, V.I., et al. 1996. Mol. Pharmacol. 50: 1541-1550.
Estado de Materia
Soluble in water (partly), ethanol (10 mM, with gentle warming), chloroform (1:20), ethyl acetate (1:55), and DMSO (25 mM, with gentle warming).
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn