NKPD1 Inhibitors
NKPD1 inhibitors encompass a diverse group of chemical compounds that can inhibit the protein's activity through various cellular pathways and biological processes. Bisphenol A, for instance, can interfere with estrogen receptor signaling, potentially leading to the downregulation of NKPD1 if it is under the control of estrogen-mediated transcription. On the other hand, Triclosan could alter NKPD1 activity by perturbing lipid biosynthesis and the essential lipid-protein interactions required for NKPD1's function. Inflammatory pathways, too, have a role, where compounds like Curcumin and Resveratrol can inhibit NKPD1 by downregulating the NF-κB pathway, which may be a regulator of NKPD1 expression.
Epigenetic modifiers such as Sodium butyrate and Sulforaphane inhibit histone deacetylases, potentially leading to altered gene expression patterns that can affect NKPD1. By increasing histone acetylation, these compounds can change the chromatin structure, making it either more or less accessible for transcription factors to bind and regulate gene expression, which in turn can inhibit or activate NKPD1 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, by acting as an endocrine disruptor, can bind to estrogen receptors, which may regulate gene expression through the estrogen response elements (EREs) in the promoters of target genes. If NKPD1 is a gene regulated by such EREs, Bisphenol A can inhibit NKPD1 expression by antagonizing normal estrogen receptor signaling. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
Triclosan, an antimicrobial that disrupts lipid biosynthesis, can alter cellular membranes and potentially the localization or function of membrane-associated proteins. If NKPD1 requires specific lipid interactions for its activity, Triclosan could inhibit NKPD1 by disrupting those essential lipid-protein interactions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, through its inhibition of the NF-κB signaling pathway, can decrease the expression of genes regulated by NF-κB. If the expression of NKPD1 is under the control of NF-κB, Curcumin can inhibit NKPD1 by preventing its transcriptional activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, by inhibiting NF-κB, may reduce the expression of pro-inflammatory genes. If NKPD1 is upregulated in an NF-κB-dependent inflammatory context, Resveratrol would then inhibit NKPD1 by attenuating the pathway necessary for its induction. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, increases histone acetylation, leading to altered gene expression. If NKPD1 expression is suppressed by histone deacetylation, Sodium butyrate can inhibit NKPD1 by maintaining histones in an acetylated state, which can silence gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, can prevent the activation of downstream signaling pathways such as Akt signaling. If NKPD1 function is dependent on PI3K/Akt pathway activation, LY294002 can inhibit NKPD1 by blocking the pathway that activates it. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can arrest cell growth and proliferation. If NKPD1 plays a role in mTOR signaling, Rapamycin can inhibit NKPD1 by halting the signaling events in which NKPD1 participates. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, a broad-spectrum kinase inhibitor, can inhibit various signal transduction pathways. If NKPD1 is activated by a kinase that Staurosporine inhibits, it can lead to decreased NKPD1 activity by inhibiting the kinase that would normally activate NKPD1. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose is a glycolysis inhibitor which can limit ATP production. If NKPD1 activity relies on ATP from glycolysis, 2-Deoxy-D-glucose can inhibit NKPD1 by depleting the cellular energy required for its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which acts in the MAPK/ERK pathway. If NKPD1 is regulated by or involved in this pathway, PD98059 can inhibit NKPD1 by blocking the signaling required for its activation. | ||||||