NHERF-2 Inhibitors
NHERF-2 Inhibitors encompass various chemicals that indirectly target or influence the activity of Na+/H+ Exchanger Regulatory Factor 2 (NHERF-2). These inhibitors function by modulating signaling pathways and cellular processes related to or influenced by NHERF-2, rather than directly binding to or inhibiting the protein itself.
The primary mechanism through which these inhibitors function involves the modulation of various signaling pathways in which NHERF-2 is involved. Compounds like Forskolin, which activates adenylate cyclase, can indirectly affect pathways regulated by NHERF-2, leading to changes in cellular transport and signal transduction mechanisms. Tyrosine kinase inhibitors such as Genistein, Dasatinib, and Imatinib may influence signaling pathways that interact with or are regulated by NHERF-2, given the protein's role in signal transduction. Additionally, inhibitors of key signaling pathways like MEK (PD 98059, U0126), PI3K (LY294002, Wortmannin), mTOR (Rapamycin), and MAPKs (SB203580, SP600125) can impact NHERF-2 related signaling. By inhibiting these pathways, these compounds can alter the cellular processes in which NHERF-2 is involved, such as ion transport regulation and cell signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor, could indirectly affect signaling pathways involving NHERF-2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK, which is part of the MAPK/ERK pathway, potentially affecting NHERF-2 related signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR signaling, potentially affecting pathways associated with NHERF-2. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Src family kinase inhibitor, may indirectly influence NHERF-2 related signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, another MAPK pathway component, potentially affecting NHERF-2. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A tyrosine kinase inhibitor, may have indirect effects on NHERF-2 signaling pathways. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Inhibits Bcr-Abl and other tyrosine kinases, potentially affecting NHERF-2 related signaling. | ||||||