NHE-7 Activators
NHE-7, also known as SLC9A7, is a protein encoded by the SLC9A7 gene in humans. It belongs to the solute carrier family 9 (SLC9), which comprises the Na+/H+ exchanger (NHE) family. NHE proteins are integral membrane proteins involved in regulating intracellular pH and cell volume by exchanging intracellular hydrogen ions (H+) for extracellular sodium ions (Na+).NHE-7 is an isoform of the NHE family. Unlike some other NHE isoforms, which are found in the plasma membrane and involved in the regulation of cytosolic pH, NHE-7 is primarily located in intracellular compartments. This suggests a role in regulating the pH in these compartments, which is essential for a variety of cellular processes, including protein processing, trafficking, and degradation.
The exact physiological role of NHE-7 is not fully understood, but it is believed to be involved in the regulation of intracellular ion homeostasis and volume. Given its intracellular location, NHE-7 could potentially play a role in the regulation of organelle function and in processes such as endocytosis and protein trafficking.Alterations in the SLC9A7 gene or NHE-7 protein function could potentially affect these cellular processes and contribute to disease states. However, the specific links between NHE-7 and disease are still areas of active research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $55.00 $240.00 $333.00 $562.00 $988.00 | ||
Hydrochlorothiazide, a diuretic affecting sodium transport, might indirectly affect NHE-7's role in sodium and pH regulation. | ||||||
Cariporide | 159138-80-4 | sc-337619A sc-337619 | 10 mg 100 mg | $87.00 $729.00 | 31 | |
Cariporide, a Na+/H+ exchange inhibitor, can potentially impact NHE-7's function in regulating ion exchange and cellular pH. | ||||||
Acetazolamide | 59-66-5 | sc-214461 sc-214461A sc-214461B sc-214461C sc-214461D sc-214461E sc-214461F | 10 g 25 g 100 g 250 g 500 g 1 kg 2 kg | $81.00 $177.00 $434.00 $541.00 $883.00 $1479.00 $2244.00 | 1 | |
Acetazolamide, a carbonic anhydrase inhibitor, affects acid-base balance, potentially impacting NHE-7 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin found in green tea, can influence various signaling pathways, potentially modulating NHE-7 activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a corticosteroid, can influence ion transport and cellular metabolism, potentially affecting NHE-7. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Bumetanide, a loop diuretic, impacts ion transport, which might have indirect effects on NHE-7 function. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Spironolactone, a potassium-sparing diuretic, can affect ion homeostasis, potentially influencing NHE-7 activity. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan, an angiotensin II receptor blocker, can influence electrolyte balance, potentially affecting NHE-7's function. | ||||||