Ng23 Activators
Ng23 (SAPCD1) activators encompass a range of chemical compounds that indirectly enhance its functional activity through various signaling pathways. Retinoic Acid, pivotal in the retinoic acid signaling pathway, indirectly augments Ng23 activity in cell proliferation and differentiation. Similarly, Epidermal Growth Factor (EGF) activates its receptor pathway, indirectly boosting Ng23's role in these processes. Forskolin, by elevating cAMP and activating PKA, indirectly influences Ng23 by phosphorylating proteins that interact with it, enhancing its functional activity in cell cycle regulation. Phorbol 12-myristate 13-acetate (PMA), a Protein Kinase C (PKC) activator, and LY294002, a PI3K inhibitor, work in tandem to modulate pathways intersecting with Ng23's role in cell proliferation and differentiation, thereby indirectly enhancing its activity. Wortmannin, another PI3K inhibitor, similarly shifts cellular signaling dynamics, favoring pathways where Ng23 is involved.
The narrative of Ng23 activation continues with compounds like U0126 and SB203580, both inhibitors in the MAPK pathway, which by affecting cell cycle regulation and differentiation pathways, indirectly boost Ng23's functional role. Sphingosine-1-phosphate, involved in cell survival signaling, and Rapamycin, an mTOR inhibitor, also contribute by modulating pathways central to Ng23's activities in cell proliferation and differentiation. PD98059, another MEK inhibitor in the MAPK/ERK pathway, enhances Ng23's involvement in similar processes. Lastly, Thapsigargin elevates intracellular calcium levels, indirectly influencing Ng23. This broad spectrum of activators, through their targeted effects on cellular signaling, collectively facilitates the enhancement of Ng23 mediated functions, predominantly in cell cycle regulation and differentiation, without necessitating the upregulation of its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences the retinoic acid signaling pathway. Ng23 (SAPCD1) is implicated in the regulation of cell proliferation and differentiation, processes that are profoundly affected by retinoic acid signaling. Retinoic Acid, therefore, enhances the functional activity of Ng23 by modulating these cellular processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, activating PKA. Ng23, being involved in cell cycle regulation, can be indirectly affected as PKA can phosphorylate proteins that interact with or modulate the activity of Ng23, leading to its enhanced functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC). Since Ng23 is involved in cell proliferation and differentiation, PKC activation can indirectly enhance Ng23 activity by modulating pathways that intersect with the cell cycle and differentiation processes where Ng23 plays a role. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it can shift cellular signaling pathways, potentially enhancing Ng23 activity indirectly by affecting related cell cycle and differentiation pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, similar to LY294002. It indirectly enhances Ng23 activity by altering the balance of cell signaling pathways, especially those related to cell proliferation and differentiation where Ng23 is involved. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, part of the MAPK pathway. By inhibiting MEK, it can indirectly enhance the activity of Ng23 by affecting cell cycle regulation and differentiation pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it indirectly enhances Ng23 activity by influencing cell cycle and differentiation pathways, processes in which Ng23 is implicated. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is involved in signaling related to cell proliferation and survival. By influencing these pathways, it can indirectly enhance the activity of Ng23 in cell cycle regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in cell growth and proliferation. By inhibiting mTOR, it can indirectly enhance Ng23 activity by modulating cell cycle and differentiation pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is a part of the MAPK/ERK pathway. By inhibiting MEK, it indirectly enhances Ng23 activity, particularly in cell cycle regulation and differentiation. | ||||||