NF kappa B Inhibitors
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Items 21 to 29 of 29 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl 3,4-Dihydroxycinnamate | 66648-50-8 | sc-205930 sc-205930A | 25 mg 250 mg | $51.00 $360.00 | ||
Ethyl 3,4-Dihydroxycinnamate exhibits notable effects on the NF-kappa B signaling pathway by enhancing the degradation of IκB proteins, leading to the release and activation of NF-kappa B dimers. Its unique hydroxyl groups facilitate hydrogen bonding and hydrophobic interactions, promoting stability in protein complexes. This compound also influences the phosphorylation of signaling intermediates, thereby modulating gene expression and cellular responses to stress and inflammation. | ||||||
CAY10512 | 139141-12-1 | sc-205237 sc-205237A | 10 mg 100 mg | $67.00 $539.00 | ||
CAY10512 acts as a potent modulator of the NF-kappa B pathway, primarily through its ability to disrupt the IκB-NF-kappa B complex. This compound engages in specific interactions with key signaling proteins, promoting their post-translational modifications. Its unique structural features enhance binding affinity, leading to altered kinetics in downstream signaling cascades. Additionally, CAY10512 influences cellular localization of NF-kappa B, thereby affecting transcriptional activity and cellular homeostasis. | ||||||
N-Stearoyl Phytosphingosine | 34354-88-6 | sc-391606 | 5 mg | $540.00 | ||
N-Stearoyl Phytosphingosine exhibits a distinctive role in modulating the NF-kappa B signaling pathway by stabilizing the IκB protein, which inhibits NF-kappa B translocation to the nucleus. Its unique lipid structure facilitates membrane interactions, enhancing its bioavailability and promoting specific protein interactions. This compound also influences the phosphorylation state of signaling intermediates, thereby fine-tuning the kinetics of inflammatory responses and cellular stress pathways. | ||||||
Palmitic Acid methyl ester | 112-39-0 | sc-204829 sc-204829A sc-204829B sc-204829C | 1 g 5 g 10 g 25 g | $15.00 $58.00 $112.00 $230.00 | ||
Palmitic Acid methyl ester plays a significant role in modulating cellular signaling by influencing the NF-kappa B pathway. Its unique esterified structure enhances lipid solubility, promoting effective membrane incorporation and interaction with lipid rafts. This compound can alter the dynamics of protein complexes involved in the pathway, potentially affecting the phosphorylation and degradation of IκB proteins. Additionally, its hydrophobic characteristics may impact cellular stress responses and inflammatory signaling cascades. | ||||||
9-Methylstreptimidone | 51867-94-8 | sc-391477 | 1 mg | $612.00 | ||
9-Methylstreptimidone exhibits intriguing interactions within the NF-kappa B signaling pathway, primarily through its ability to modulate protein-protein interactions. Its unique structural features facilitate the stabilization of specific transcription factors, influencing their nuclear translocation. This compound can also alter the kinetics of downstream signaling events, potentially affecting the expression of target genes. Furthermore, its distinct hydrophobicity may enhance its affinity for membrane-associated proteins, impacting cellular responses to stress and inflammation. | ||||||
Yangonin | 500-62-9 | sc-205889 sc-205889A | 5 mg 10 mg | $268.00 $510.00 | 1 | |
Yangonin is a notable compound that interacts with the NF-kappa B signaling pathway, primarily through its ability to modulate the phosphorylation of IκB proteins. This modulation affects the translocation of NF-kappa B to the nucleus, influencing gene expression. Its unique structural features facilitate specific interactions with key regulatory proteins, altering the kinetics of the pathway and potentially impacting cellular responses to stress and inflammation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is a selective inhibitor of NF-kappa B activation, primarily acting by disrupting the phosphorylation of IκBα. This compound uniquely stabilizes IκBα, preventing its degradation and subsequent release of NF-kappa B dimers. The compound's distinct molecular interactions with the IκB kinase complex alter the dynamics of the signaling cascade, effectively modulating cellular responses and influencing transcriptional regulation in various biological contexts. | ||||||
Diethyldithiocarbamic Acid-d10 Sodium Salt Trihydrate | sc-218215 | 1 mg | $360.00 | |||
Diethyldithiocarbamic Acid-d10 Sodium Salt Trihydrate serves as a potent modulator of NF-kappa B signaling pathways. Its unique structure facilitates the chelation of metal ions, which can influence the activity of various kinases involved in the NF-kappa B pathway. By altering the redox state within cells, it impacts the phosphorylation processes that govern IκBα stability, thereby affecting the translocation of NF-kappa B to the nucleus and its transcriptional activity. | ||||||
4-Aminosalicylic acid sodium salt dihydrate | 6018-19-5 | sc-352380 sc-352380A | 100 g 500 g | $66.00 $263.00 | ||
4-Aminosalicylic acid sodium salt dihydrate acts as a significant regulator of NF-kappa B activity through its ability to interact with specific cellular components. Its unique amino and carboxyl functional groups enable it to form hydrogen bonds and ionic interactions, influencing protein conformation and stability. This compound can modulate the ubiquitination processes of IκB proteins, thereby affecting the release and nuclear localization of NF-kappa B dimers, ultimately impacting gene expression dynamics. | ||||||