Date published: 2026-5-24

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9-Methylstreptimidone (CAS 51867-94-8)

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Application:
9-Methylstreptimidone is a member of the glutarimide family that exhibits antifungal and prophylactic antiviral activity
CAS Number:
51867-94-8
Molecular Weight:
307.38
Molecular Formula:
C17H25NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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9-Methylstreptimidone is a synthetic analog derived from the streptimidone family of compounds, characterized by its unique molecular structure that enables specific interactions with various biomolecular targets. Primarily researched within the context of microbiology and chemical biology, this compound has garnered attention for its ability to modulate enzyme activity and influence microbial signaling pathways, thereby serving as a tool to unravel the complexities of microbial communication and resistance mechanisms. Its mechanism of action, while not fully elucidated, is believed to involve the disruption of nucleic acid processes and the alteration of protein synthesis within microbial cells, offering insights into potential antimicrobial strategies. The role of 9-Methylstreptimidone in research extends to its use as a molecular probe to study the function of essential biomolecules, facilitating the exploration of microbial physiology and the development of novel biochemical methodologies. Through its application in these areas, 9-Methylstreptimidone contributes to the broader understanding of microbial dynamics and the identification of new targets for antimicrobial intervention.


9-Methylstreptimidone (CAS 51867-94-8) References

  1. Isolation, structure determination and biological activity of a new glutarimide antibiotic, S632A3.  |  Cheng, CL., et al. 2006. J Asian Nat Prod Res. 8: 55-60. PMID: 16753783
  2. Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-kappaB.  |  Ishikawa, Y., et al. 2009. Bioorg Med Chem Lett. 19: 1726-8. PMID: 19231181
  3. Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone.  |  Takeiri, M., et al. 2011. Inflamm Res. 60: 879-88. PMID: 21625968
  4. Structure-activity relationship of 9-methylstreptimidone, a compound that induces apoptosis selectively in adult T-cell leukemia cells.  |  Takeiri, M., et al. 2012. Oncol Res. 20: 7-14. PMID: 23035360
  5. Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation.  |  Wang, B., et al. 2013. Org Lett. 15: 1278-81. PMID: 23438151
  6. A new glutarimide derivative from marine sponge-derived Streptomyces anulatus S71.  |  Sun, D., et al. 2014. Nat Prod Res. 28: 1602-6. PMID: 24949797
  7. Inhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide.  |  Koide, N., et al. 2015. Int Immunopharmacol. 25: 162-8. PMID: 25617668
  8. Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference.  |  Pimentel-Elardo, SM., et al. 2015. ACS Chem Biol. 10: 2616-23. PMID: 26352211
  9. Two new glutarimide antibiotics from Streptomyces sp. HS-NF-780.  |  Zhao, XL., et al. 2019. J Antibiot (Tokyo). 72: 241-245. PMID: 30696946
  10. Establishing cell painting in a smaller chemical biology lab - A report from the frontier.  |  Svenningsen, EB. and Poulsen, TB. 2019. Bioorg Med Chem. 27: 2609-2615. PMID: 30935791
  11. Streptomyces botrytidirepellens sp. nov., a novel actinomycete with antifungal activity against Botrytis cinerea.  |  Jiang, M., et al. 2021. Int J Syst Evol Microbiol. 71: PMID: 34520340
  12. Effect of an interferon inducer, 9-methylstreptimidone, on Candida albicans infection in mice.  |  Umenai, T., et al. 1978. Antimicrob Agents Chemother. 13: 939-43. PMID: 354522
  13. Isolation, structure determination and biological activities of a novel antifungal antibiotic, S-632-C, closely related to glutarimide antibiotics.  |  Urakawa, A., et al. 1993. J Antibiot (Tokyo). 46: 1827-33. PMID: 8294240
  14. Antiviral and interferon-inducing activity of a new glutarimide antibiotic, 9-methylstreptimidone.  |  Saito, N., et al. 1976. Antimicrob Agents Chemother. 10: 14-9. PMID: 984746

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

9-Methylstreptimidone, 1 mg

sc-391477
1 mg
$612.00