Neurotrypsin Inhibitors
Neurotrypsin inhibitors belong to a distinct chemical class that plays a crucial role in modulating the activity of neurotrypsin, an enzyme implicated in various physiological processes within the nervous system. Neurotrypsin, a serine protease predominantly expressed in the brain, is involved in the proteolytic processing of proteins associated with synaptic plasticity, cell adhesion, and axon guidance. The inhibitors of neurotrypsin act by interfering with its catalytic activity, which is essential for the precise cleavage of specific substrates. This class of compounds often exhibits a selective binding affinity to the active site of neurotrypsin, preventing its enzymatic action and influencing downstream signaling cascades.
Structurally, neurotrypsin inhibitors can possess diverse chemical frameworks, ranging from small organic molecules to more complex structures. These inhibitors typically feature functional groups and molecular motifs that facilitate specific interactions with the catalytic residues of neurotrypsin, ensuring a potent inhibitory effect. Researchers are actively exploring the structural nuances and binding kinetics of neurotrypsin inhibitors to enhance their efficacy and selectivity. Understanding the intricate details of the interaction between these inhibitors and neurotrypsin's active site is critical for the development of novel compounds with improved pharmacological properties. As investigations into the molecular mechanisms underlying neurotrypsin inhibition progress, this chemical class holds promise for advancing our comprehension of neurotrypsin-associated processes in the nervous system, opening avenues for potential future applications in research and beyond.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
Benzamidine is a reversible competitive inhibitor of trypsin-like proteases, which would include Neurotrypsin. By binding to the active site of Neurotrypsin, benzamidine hinders its proteolytic activity, thereby reducing its functional activity within the proteolytic cascade it is involved in. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
Aprotinin is a small protein protease inhibitor that inhibits several serine proteases, including Neurotrypsin. It blocks the active site of the enzyme, preventing substrate access and subsequent proteolysis. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is a reversible inhibitor of serine and cysteine proteases. It binds to the active site of Neurotrypsin, inhibiting its proteolytic function. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $153.00 $255.00 $627.00 $1163.00 $2225.00 | 3 | |
Chymostatin is a protease inhibitor that selectively inhibits chymotrypsin-like enzymes, which would also affect Neurotrypsin by competitively inhibiting its active site and thus its proteolytic activity. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Gabexate mesilate is a synthetic protease inhibitor that mainly inhibits serine proteases, including Neurotrypsin. It acts by binding to the active site of the enzyme and preventing substrate cleavage. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
Nafamostat is a broad-spectrum serine protease inhibitor that would also inhibit Neurotrypsin by competitive inhibition at the enzyme's active site, thus decreasing its functional activity. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 is an irreversible inhibitor of cysteine proteases. While Neurotrypsin is a serine protease, the inhibition of cysteine proteases in its vicinity could indirectly reduce Neurotrypsin's activity by altering proteolytic processing within the same pathway. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
AEBSF is an irreversible inhibitor of serine proteases. By covalently modifying the hydroxyl group of the active site serine, AEBSF would inhibit the proteolytic activity of Neurotrypsin. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $42.00 $179.00 $306.00 $612.00 $2040.00 $4386.00 | 5 | |
Camostat mesilate is an inhibitor of serine proteases, including trypsin-like proteases such as Neurotrypsin. It inhibits the proteolytic activity by forming a reversible complex with the enzyme's active site. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $195.00 $620.00 | 8 | |
Phosphoramidon is a metalloprotease inhibitor that, while not a direct inhibitor of serine proteases like Neurotrypsin, could indirectly affect its activity by modulating the protease network in which Neurotrypsin operates, potentially altering substrate availability. | ||||||