neuroligin X/Y Activators
Neuroligin X/Y represents a designation for a class of proteins within the neuroligin family, which plays a pivotal role in the intricate processes of synaptic formation and maintenance. These cell adhesion molecules are integral to the establishment and remodeling of synapses, the dynamic connections between neurons that enable communication within the brain. The neuroligin family participates in the precise orchestration of neural circuits, ensuring that synaptic functions are tailored to the demands of the neural environment. Variations in neuroligin expression can lead to alterations in synaptic density and plasticity, highlighting the significance of understanding the regulatory mechanisms behind these proteins. Research into neuroligin expression not only advances our comprehension of synaptic development but also provides insights into the complex molecular dialogue that underpins neural connectivity.
A spectrum of chemical compounds has been identified with the capacity to potentially act as activators of gene expression, and while none are known to specifically target neuroligin X/Y, their roles in cellular signaling pathways suggest that they could influence the expression of neuroligin proteins. Retinoic acid, a derivative of vitamin A, is well-documented for its involvement in neural differentiation and may play a role in the upregulation of neuroligin transcription. Histone modification agents, such as Trichostatin A and Sodium butyrate, alter the chromatin landscape, potentially increasing the accessibility of transcription factors to neuroligin gene promoters. Forskolin and Dibutyryl-cAMP, through their effects on cAMP signaling, could enhance neuroligin expression by stimulating the CREB transcription factor, a known regulator of neuronal gene expression. Other compounds like Beta-estradiol and Resveratrol are thought to affect gene transcription via receptor-mediated signaling and activation of specific deacetylases, respectively. These compounds, by interacting with diverse cellular pathways, may influence the expression of neuroligins, contributing to the dynamic modulation of synaptogenesis and synaptic plasticity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate neuroligin expression through retinoic acid receptor-mediated transcriptional activation, which is crucial for synaptic plasticity and neural network development. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could induce the transcription of neuroligin genes in neurons by reversing epigenetic silencing mechanisms, potentially enhancing synaptic connectivity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may stimulate the production of neuroligins by inhibiting histone deacetylase, leading to increased histone acetylation and transcriptional activation of genes involved in synaptogenesis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin might increase neuroligin gene expression by activating adenylyl cyclase and increasing intracellular cAMP levels, which can enhance the activity of transcription factors related to neuronal growth and synaptic formation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol could selectively stimulate the expression of neuroligins via estrogen receptor-mediated signaling pathways, potentially playing a role in modulating synaptic structure in response to hormonal changes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can increase acetylation of histones near neuroligin gene promoters, potentially leading to enhanced transcriptional activity and greater synaptic protein abundance. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
This cAMP analog might enhance neuroligin expression by mimicking the action of cAMP, thereby activating protein kinase A and phosphorylating transcription factors that drive synaptic protein gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA may induce the expression of neuroligins through the activation of protein kinase C, which is involved in intracellular signaling pathways that can lead to alterations in gene expression related to neuronal function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride could indirectly stimulate neuroligin expression by inhibiting glycogen synthase kinase-3 (GSK-3), which is implicated in neurodevelopmental processes and synaptic plasticity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid might promote neuroligin gene transcription by inhibiting histone deacetylase, thereby increasing histone acetylation and facilitating a more transcriptionally active chromatin state in neuron-specific genes. | ||||||