NDG1 Inhibitors
Chemical inhibitors of NDG1 can target various signaling pathways and enzymatic activities within the cell to inhibit the function of this protein. Benzamidine, as a serine protease inhibitor, can prevent protease-mediated modifications or maturation events essential for the activity of NDG1. Similarly, Bisindolylmaleimide I, by specifically inhibiting protein kinase C (PKC), can block necessary phosphorylation processes that NDG1 may depend upon for stability or interaction with other cellular components. Genistein, known for its role as a tyrosine kinase inhibitor, can disrupt critical phosphorylation events on tyrosine residues that NDG1 requires for its activation or function. LY294002 and Wortmannin, both potent inhibitors of phosphoinositide 3-kinases (PI3K), can reduce the levels of PIP3, potentially compromising the localization or function of NDG1 if it is PI3K-dependent.
Continuing with this theme, NDG1's activity can also be affected by the inhibition of various kinases involved in the mitogen-activated protein kinase (MAPK) pathways. PD98059 and U0126, as selective inhibitors of the MEK/ERK pathway, can impede the function of NDG1 if it operates within this signaling cascade. Likewise, SB203580 and SP600125, which inhibit p38 MAP kinase and c-Jun N-terminal kinase (JNK) respectively, can also diminish NDG1's activity by obstructing its potential roles within these specific MAPK pathways. The Src family tyrosine kinases, targeted by PP2, are another group of enzymes that, when inhibited, can lead to a decrease in NDG1 function if it relies on tyrosine phosphorylation. Finally, Y-27632, by inhibiting the Rho-associated protein kinase (ROCK), can affect NDG1 function if there is a reliance on the Rho/ROCK signaling pathway. PD168393, an irreversible inhibitor of EGFR tyrosine kinase, can also inhibit NDG1 by blocking upstream signaling events that NDG1 may be dependent upon for its function.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
Benzamidine is a known inhibitor of serine proteases. NDG1, being a protein involved in specific cellular pathways, may interact with proteases during its function or maturation. Benzamidine could inhibit NDG1 by preventing protease-mediated processes that are essential for NDG1's functional activity within the cell. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). NDG1 may rely on phosphorylation by PKC for its activity, stability, or interactions with other cellular components. Inhibition of PKC by Bisindolylmaleimide I could therefore inhibit NDG1 by blocking its necessary phosphorylation, thus impeding its function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. If NDG1 activity is contingent upon phosphorylation by tyrosine kinases, Genistein could inhibit this phosphorylation, thereby inhibiting the functional activity of NDG1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, and by inhibiting this kinase, it can affect pathways that are crucial for the activity of various proteins. Inhibition of PI3K could lead to a decrease in the phosphatidylinositol (3,4,5)-trisphosphate (PIP3) levels, a lipid that could be necessary for the proper localization and function of NDG1, thereby functionally inhibiting it. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which in turn inhibits ERK/MAP kinase. NDG1, which may be active downstream or as part of the MAPK pathway, would thereby be inhibited in its function due to the blockage of this pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. If NDG1 requires tyrosine kinase activity for its function or stability, then inhibition of these kinases by PP2 would result in the functional inhibition of NDG1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. If NDG1 function is mediated through p38 MAPK signaling, inhibiting this kinase would lead to the functional inhibition of NDG1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAP kinase pathway. If NDG1 operates within or downstream of this pathway, inhibition of JNK by SP600125 would inhibit the functional activity of NDG1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, and inhibiting MEK1/2 would lead to the inhibition of the downstream ERK pathway. If NDG1 is functional within this pathway, its activity would be inhibited by U0126. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, similar to LY294002. It would inhibit NDG1 function by disrupting PI3K-dependent pathways that NDG1 may rely upon for its activity. | ||||||