ND5 Activators
ND5 Activators comprise a diverse array of chemical compounds that indirectly enhance the functional activity of ND5 by targeting various cellular and molecular mechanisms that support mitochondrial integrity and biogenesis. Resveratrol and metformin, through their activation of SIRT1 and AMPK respectively, promote the deacetylation and subsequentactivation of PGC-1α, a master regulator of mitochondrial biogenesis, thereby potentially increasing the number of mitochondria and enhancing the expression of mitochondrial proteins, including ND5. Nicotinamide adenine dinucleotide (NAD+), as a fundamental metabolite, increases the pool of NAD+/NADH and supports the electron transport chain, of which ND5 is an integral part, thus enhancing mitochondrial respiratory efficiency. Coenzyme Q10, α-Lipoic acid, and Spermidine each contribute to the maintenance and turnover of mitochondria, where Coenzyme Q10 acts as an electron carrier in the respiratory chain, α-Lipoic acid as an antioxidant that preserves mitochondrial function, and Spermidine through autophagy induction leading to new mitochondria with a relative increase in ND5.
Curcumin, Pyrroloquinoline quinone (PQQ), and Epigallocatechin gallate (EGCG) all act to reduce oxidative stress and protect mitochondrial integrity, leading to improved mitochondrial function and an indirect enhancement of ND5 activity. Bezafibrate, by acting as a PPAR agonist, upregulates proteins involved in fatty acid oxidation, which could result in the increased activity of mitochondrial enzymes, including ND5. Similarly, leucine stimulates the mTOR pathway, promoting protein synthesis and mitochondrial biogenesis, which includes the synthesis of ND5. Lastly, Sulforaphane activates the Nrf2 pathway, leading to a heightened defense against oxidative damage and supporting mitochondrial function, which is conducive to the activity of ND5 within the electron transport chain.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes, can enhance the activity of ND5 by improving mitochondrial function. It promotes the activation of SIRT1, leading to deacetylation and activation of PGC-1α, which can increase mitochondrial biogenesis and thereby potentially enhance the activity of mitochondrial proteins including ND5. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a coenzyme that is central to metabolism. Found in all living cells, NAD+ can enhance ND5 activity indirectly by increasing the overall pool of NAD+/NADH, and supporting the electron transport chain where ND5 is a crucial component, thus increasing mitochondrial respiration efficiency. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin, commonly used as an anti-diabetic drug, can influence ND5 activity by activating AMP-activated protein kinase (AMPK). AMPK activation can lead to increased mitochondrial biogenesis through PGC-1α, which can enhance the expression and activity of mitochondrial proteins, including ND5. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 functions as an electron carrier within the mitochondrial respiratory chain. It can enhance ND5 activity by maintaining the electron flow through complex I, where ND5 is located, optimizing mitochondrial respiration and ATP production. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic acid acts as a mitochondrial antioxidant. By reducing oxidative stress, it can preserve mitochondrial function and indirectly enhance ND5 activity by preventing oxidative damage to complex I subunits and improving the efficiency of the electron transport chain. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine, through the induction of autophagy, can lead to the removal of dysfunctional mitochondria and promote the generation of new ones. This turnover can result in a relative increase in mitochondrial proteins, including ND5, thereby enhancing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known for its anti-inflammatory properties and can modulate mitochondrial function. It can enhance ND5 activity by promoting mitochondrial biogenesis through the activation of AMPK and subsequent upregulation of PGC-1α, leading to increased ND5 expression in new mitochondria. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
PQQ is a redox cofactor and antioxidant that can protect mitochondria from oxidative stress. By preserving mitochondrial integrity, PQQ can enhance ND5 activity by maintaining the optimal function of the electron transport chain where ND5 is essential. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the main catechin in green tea, can enhance ND5 activity through its antioxidant properties, reducing oxidative damage to mitochondrial DNA and proteins, leading to improved mitochondrial function and indirectly enhancing the activity of ND5 as a component of the electron transport chain. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate is a fibric acid derivative that acts as a peroxisome proliferator-activated receptor (PPAR) agonist. By activating PPAR, it can lead to the upregulation of proteins involved in fatty acid oxidation and energy production, including mitochondrial enzymes, thereby potentially enhancing ND5 activity within the electron transport chain. | ||||||