NCC Activators
The sodium-chloride symporter, commonly referred to as NCC, is a protein integral to the body's ability to maintain fluid and electrolyte balance. Encoded by the SLC12A3 gene, NCC facilitates the reabsorption of sodium and chloride ions from the filtrate in the kidney's distal convoluted tubules back into the bloodstream. This transporter is pivotal in the fine-tuning of renal sodium handling, a process essential for maintaining blood pressure and volume. As an electroneutral symporter, NCC operates under the regulation of various physiological signals and interacts with a network of intracellular pathways to adjust its activity in line with the body's fluctuating needs. The expression of NCC can be influenced by a myriad of factors that engage at the genomic level, resulting in alterations in the amount of protein produced and available for ion transport.
Several specific chemical compounds have been identified that may serve as activators to induce the expression of NCC, each interacting through unique biochemical pathways. For instance, aldosterone, a hormone known to control sodium absorption, can promote the transcription of NCC by binding to mineralocorticoid receptors, which then interact with DNA at specific sites to initiate gene expression. Similarly, insulin may enhance NCC expression by engaging with its receptor, setting off a cascade of intracellular events that culminate in the upregulation of genes involved in sodium reabsorption. Intracellular messengers like cyclic AMP (cAMP) also play a role in the induction of NCC, by activating protein kinase A (PKA), which can phosphorylate transcription factors that drive NCC gene expression. Moreover, factors such as vitamin D3, through its hormonal form, can interact with nuclear receptors to stimulate the transcription of NCC. Each of these compounds, among others, participates in complex signaling networks that converge on the control of NCC expression, underlining the sophisticated regulatory systems that govern renal sodium and chloride balance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aldosterone | 52-39-1 | sc-210774 sc-210774A sc-210774B sc-210774C sc-210774D sc-210774E | 2 mg 5 mg 10 mg 50 mg 100 mg 250 mg | $259.00 $213.00 $317.00 $1550.00 $3074.00 $7637.00 | 1 | |
Aldosterone can upregulate NCC by binding to mineralocorticoid receptors, leading to increased gene transcription of sodium reabsorption channels in kidney cells. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin has the potential to stimulate NCC expression through its role in glucose metabolism, possibly by enhancing electrolyte transport in response to metabolic demands. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Adenosine 3',5'-cyclic monophosphate elevates NCC production by activating protein kinase A (PKA), which phosphorylates CREB, a transcription factor that may increase NCC gene transcription. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol may stimulate NCC expression by its hormonal form calcitriol's interaction with vitamin D receptors, leading to the activation of signal transduction pathways involved in mineral ion homeostasis. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II could increase NCC transcription through the AT1 receptor, which prompts signaling cascades involved in blood pressure and sodium balance, possibly resulting in elevated NCC expression. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine might upregulate NCC by engaging D1-like receptors, which activate adenylate cyclase, increasing intracellular cAMP levels, and potentially enhancing the transcription of genes coding for sodium transporters. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 may indirectly upregulate NCC by altering renal blood flow and filtration rates, which could trigger compensatory increases in sodium reabsorption capacity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide could stimulate NCC expression by acting as a signaling molecule that triggers redox-sensitive transcription factors, possibly leading to enhanced gene transcription associated with ion transport. | ||||||
D(−)Mannitol | 69-65-8 | sc-203020A sc-203020 | 50 g 100 g | $10.00 $19.00 | 2 | |
Mannitol, when used to create a hyperosmolar environment, could induce the synthesis of NCC by osmotically triggering cellular pathways that compensate for changes in ion concentration. | ||||||