NC2α Activators
NC2α Activators consist of a collection of chemical compounds that can enhance the functional activity of NC2α, a protein primarily involved in the regulation of intracellular pH. These compounds primarily exert their effects by manipulating the cyclic AMP (cAMP)-protein kinase A (PKA) signaling pathway. Certain compounds in this class, such as forskolin, directly activate adenylate cyclase to increase intracellular cAMP levels. Others, such as epinephrine, norepinephrine, dopamine, histamine, glucagon, and serotonin, increase cAMP levels indirectly by binding to respective receptors that are positively coupled to adenylate cyclase. Increased intracellular cAMP levels lead to activation of PKA, which can phosphorylate and activate NC2α.
Other compounds in the NC2α Activators class, such as IBMX and rolipram, prevent the degradation of cAMP by inhibiting phosphodiesterases, thus maintaining high intracellular cAMP levels that can promote NC2α activation. Okadaic acid, on the other hand, enhances NC2α activity by preventing its dephosphorylation and inactivation. The action of these diverse compounds converges on the cAMP-PKA signaling pathway, ultimately leading to enhanced functional activity of NC2α. In summary, NC2α activators, through various mechanisms, all serve to regulate intracellular pH by enhancing the function of NC2α via the cAMP-PKA signaling pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Cyclic AMP (cAMP) is a secondary messenger that can enhance the activity of NC2α via its role in regulating intracellular pH. NC2α is a sodium/bicarbonate co-transporter that functions to extrude intracellular acid. The production of cAMP can activate protein kinase A (PKA), which phosphorylates and activates NC2α, leading to an increase in bicarbonate transport and ensuing alkalinization of the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cAMP. Increased cAMP levels can promote the activation of PKA, which in turn activates NC2α, thus enhancing its bicarbonate transport function. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) is an autocrine and paracrine mediator that can indirectly activate NC2α by increasing intracellular cAMP levels, thus leading to PKA activation and subsequent enhancement of NC2α function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a nonselective inhibitor of phosphodiesterases, the enzymes that degrade cAMP. By increasing intracellular cAMP levels, IBMX can promote PKA-dependent phosphorylation and activation of NC2α. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, which specializes in the degradation of cAMP. By preventing cAMP degradation, Rolipram can enhance NC2α function via PKA activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. It can enhance NC2α activity by preventing the dephosphorylation and inactivation of NC2α that is catalyzed by these phosphatases. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine can bind to β-adrenergic receptors, leading to an increase in cAMP production. This in turn activates PKA, which enhances the activity of NC2α. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine, like epinephrine, can bind to β-adrenergic receptors and stimulate cAMP production, leading to NC2α activation via PKA. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to D1-like dopamine receptors, which are positively coupled to adenylate cyclase. This leads to an increase in cAMP levels and subsequent activation of NC2α via PKA. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to H2 histamine receptors, which are positively coupled to adenylate cyclase, leading to an increase in cAMP levels and NC2α activation via PKA. | ||||||