NC2α Inhibitors
Chemical inhibitors of NC2α can exert their inhibitory action through various mechanisms that involve the modulation of cellular signaling pathways and transcriptional machinery, to which NC2α is functionally related. Wortmannin and LY294002, for example, are inhibitors of phosphoinositide 3-kinases (PI3Ks), which play a critical role in multiple cellular processes including cell growth, proliferation, and survival. By inhibiting PI3K activity, these chemicals can reduce the phosphorylation of downstream targets involved in the regulation of transcription. This reduction in phosphorylation can lead to changes in transcription factor activity and chromatin structure, thereby inhibiting the function of NC2α by altering the transcriptional environment. Similarly, rapamycin inhibits the mammalian target of rapamycin (mTOR), a kinase that is central to cell growth and proliferation, and by doing so, it can alter the transcriptional landscape and potentially inhibit NC2α's role in transcriptional processes.
Further, inhibitors like Trichostatin A and SAHA (Vorinostat) which target histone deacetylases, as well as 5-Azacytidine, which inhibits DNA methyltransferases, can change the epigenetic state of chromatin. These changes in the acetylation and methylation status of histones and DNA respectively can influence gene expression patterns and chromatin accessibility. By affecting these epigenetic marks, these inhibitors can have a substantial impact on the chromatin state and gene expression, thereby inhibiting NC2α by affecting the transcriptional programs it helps regulate. Kinase inhibitors such as Sunitinib, Sorafenib, and Imatinib can disrupt various signaling pathways by targeting multiple receptor tyrosine kinases and other kinases, leading to alterations in cell signaling that indirectly affect the transcriptional processes NC2α is involved with. Proteasome inhibition by Bortezomib can lead to the accumulation of proteins that are normally targeted for degradation, which in turn can influence the transcriptional machinery and its associated regulatory processes, indirectly leading to the inhibition of NC2α. Additionally, chemicals like Paclitaxel and Camptothecin can disrupt cell division and DNA replication processes; Paclitaxel through stabilization of microtubules, and Camptothecin as a topoisomerase I inhibitor, respectively. These disruptions can have downstream effects on cellular signaling and transcriptional regulation, thus leading to the inhibition of the NC2α protein and its role in transcription.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). NC2α is known to interact with transcriptional machinery, and PI3K signaling can influence transcription factor activity and chromatin structure, potentially inhibiting the function of NC2α by altering the transcriptional environment where NC2α operates. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of PI3K. By inhibiting PI3K, LY294002 can reduce the phosphorylation of downstream targets that are involved in the regulation of transcription and chromatin remodeling, thereby indirectly inhibiting NC2α function by changing the cellular transcriptional state. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), a central regulator of cell growth and proliferation. mTOR influences transcription and may alter the transcriptional environment and machinery to which NC2α is functionally related, leading to its inhibition. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By changing the acetylation status of histones, it can alter the expression of genes and the structure of chromatin. This can inhibit NC2α by affecting the chromatin state and thus the transcriptional processes NC2α is involved in. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to hypomethylation of DNA and affecting gene expression. By changing gene expression patterns, it indirectly inhibits NC2α by affecting the transcriptional programs that NC2α helps regulate. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a histone deacetylase inhibitor, similar to Trichostatin A. It acts to alter chromatin structure and gene expression, which can lead to the inhibition of NC2α by changing the transcription environment and processes it is involved in. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib inhibits multiple receptor tyrosine kinases, which may affect various signaling pathways, including those involved in the regulation of transcription and chromatin structure. This could lead to inhibition of NC2α by altering its functional landscape. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor that targets several enzymes involved in cell signaling, proliferation, and survival. It may inhibit NC2α indirectly by altering signaling pathways that regulate transcription factors and chromatin structure related to NC2α's function. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor, known to inhibit Bcr-Abl and other kinases. It can lead to changes in signaling pathways that indirectly inhibit NC2α by affecting the transcription machinery and regulatory processes it is involved in. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can lead to the accumulation of regulatory proteins that are normally degraded. This can inhibit NC2α by affecting the balance and function of proteins involved in the transcription processes where NC2α is active. | ||||||