NAT-8L Activators
NAT-8L Activators are a diverse group of chemical compounds that enhance the functional activity of NAT-8L by providing essential molecules or indirectly influencing the enzymatic processes it is involved in. S-Adenosylmethionine and Acetyl-CoA are direct contributors to the acetylation reaction catalyzed by NAT-8L, with the former donating a methyl group and the latter providing an acetyl group, both of which are necessary for the transferase activity. Nicotinamide adenine dinucleotide(NAD+) and reduced Glutathione act as supportive agents, with NAD+ maintaining a favorable redox state for enzymatic activities and Glutathione protecting NAT-8L from oxidative damage, thus indirectly maintaining its activity. Zinc and Magnesium may not be direct cofactors for NAT-8L, but they play significant roles in maintaining the structural integrity and stability of enzymes, which can indirectly result in enhanced NAT-8L activity. Spermidine and Oleic acid, though not directly involved with NAT-8L function, contribute to overall cellular homeostasis; Spermidine by improving protein synthesis and function and Oleic acid by affecting membrane dynamics and potentially the localization of NAT-8L.
Furthermore, Sodium butyrate, by inhibiting histone deacetylases, may facilitate a chromatin environment that is conducive to the expression of NAT-8L, while Folic acid supports the synthesis of S-Adenosylmethionine, a critical substrate for NAT-8L's enzymatic action. Pyridoxal phosphate is crucial for general enzyme activity and could indirectly benefit NAT-8L function by ensuring a healthy cellular metabolic state. Lastly, Alpha-ketoglutarate feeds into the Krebs cycle, which can result in increased levels of Acetyl-CoA, thereby indirectly enhancing NAT-8L's acetyltransferase activity. Together, these activators create an environment that boosts the activity of NAT-8L, ensuring efficient acetylation of substrates without the need for direct interaction or modification of the enzyme itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
Acetyl-CoA serves as an acetyl group donor in various enzymatic reactions. It is essential for the acetyltransferase activity of NAT-8L, which transfers an acetyl group to its substrates. Elevated levels of Acetyl-CoA can enhance the functional activity of NAT-8L by providing more of the necessary acetyl groups for its reactions. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor found in all living cells, and it is involved in redox reactions. Although NAT-8L is not directly involved in these reactions, increased NAD+ levels can indirectly enhance NAT-8L activity by maintaining a favorable redox state for enzymatic activities, including acetylation processes. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione in its reduced form serves as an important antioxidant in cells. Its presence can protect NAT-8L from oxidative damage, thus maintaining its activity. Additionally, glutathione conjugation is a parallel detoxification pathway that complements NAT-8L mediated acetylation, potentially enhancing its activity indirectly. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a trace element that is known to play a role in the stabilization of the structure of many proteins. While NAT-8L is not known to be a zinc finger protein, zinc can potentially enhance the structural stability of NAT-8L, thereby indirectly increasing its enzymatic activity. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is a polyamine that is involved in cellular metabolism and has roles in enhancing protein synthesis. By facilitating protein stability and function, spermidine could indirectly enhance the activity of NAT-8L. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a monounsaturated fatty acid that affects membrane fluidity. It can indirectly enhance NAT-8L activity by altering membrane lipid composition, which could affect the localization and function of membrane-associated enzymes like NAT-8L. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that serves as an inhibitor of histone deacetylases (HDACs). By inhibiting HDACs, it can lead to a more relaxed chromatin structure, possibly enhancing the expression of genes including those encoding transferases like NAT-8L. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic acid is involved in one-carbon metabolism, which is crucial for the generation of S-Adenosylmethionine. By promoting the availability of S-Adenosylmethionine, folic acid can indirectly enhance the activity of NAT-8L. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal phosphate is the active form of vitamin B6 and acts as a coenzyme in a variety of enzymatic reactions. While not directly involved with NAT-8L's activity, it could potentially enhance NAT-8L function by maintaining overall cellular enzyme activity and metabolism. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-ketoglutarate is an important biological compound in the Krebs cycle. Enhanced Krebs cycle activity can lead to increased levels of Acetyl-CoA, indirectly supporting the acetyltransferase action of NAT-8L. | ||||||