NARG2 Activators
NARG2 Activators are a class of chemical compounds that play a role in indirectly enhancing the functional activity of NARG2 by modulating various signaling pathways and biological processes. For example, Forskolin and IBMX both act to increase intracellular cAMP levels, which in turn activates PKA. The activated PKA may phosphorylate otherNARG2 Activators are a class of chemical compounds that play a role in indirectly enhancing the functional activity of NARG2 by modulating various signaling pathways and biological processes. For example, Forskolin and IBMX both act to increase intracellular cAMP levels, which in turn activates PKA. The activated PKA may phosphorylate other proteins that interact with or regulate NARG2, thereby enhancing its activity. Similarly, PMA, through its activation of PKC, could initiate a cascade of phosphorylation events that culminate in the activation of NARG2. Additionally, A23187 and Thapsigargin disrupt calcium homeostasis, which might lead to the activation of calcium-dependent kinases that enhance NARG2's activity. EGCG, by inhibiting competitive kinases, and the PI3K inhibitors LY294002 and Wortmannin, by altering the PI3K/AKT signaling axis, could create a cellular environment that indirectly favors NARG2's enhanced functional role.
Further to these mechanisms, U0126 and SB203580 selectively inhibit MEK1/2 and p38 MAPK, respectively, potentially shifting the signaling equilibrium towards pathways where NARG2 activity is upregulated as a compensatory response. Sphingosine-1-phosphate engages its receptors to trigger signaling pathways that could facilitate the enhancement of NARG2 activity. Conversely, Staurosporine, despite being a broad-spectrum kinase inhibitor, may inadvertently lead to the selective activation of NARG2 by inhibiting kinases that negatively regulate NARG2's function. Collectively, these compounds, through their specific and varied effects on intracellular signaling pathways, contribute to the functional activation of NARG2 without directly affecting its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator, which increases cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate proteins that regulate the function of NARG2, leading to its enhanced activity in cellular processes. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP. By maintaining higher levels of cAMP, IBMX indirectly supports the PKA-mediated phosphorylation of proteins that can increase the activity of NARG2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to downstream signaling events that enhance the activity of proteins like NARG2 by modulating their function within the cell. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases could then phosphorylate and enhance the activity of NARG2 or proteins that modulate NARG2's function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that can inhibit certain types of kinases. By inhibiting competitive kinases, EGCG could shift the equilibrium in cellular signaling pathways, indirectly enhancing the activity of NARG2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that alters the PI3K/AKT pathway. By inhibiting PI3K, LY294002 may affect downstream signaling events that indirectly enhance the activity of NARG2 through altered cellular responses. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that can activate sphingosine-1-phosphate receptors, leading to varied cellular responses. Activation of these receptors may enhance the activity of NARG2 through related signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that disrupts calcium homeostasis, leading to increased cytosolic calcium levels. This elevation in calcium could indirectly enhance NARG2 activity by engaging calcium-dependent signaling mechanisms. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, which could paradoxically enhance NARG2 activity by inhibiting kinases that normally keep NARG2 activity in check, thus lifting their inhibition and allowing NARG2 to be more active. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. By inhibiting p38 MAPK, SB203580 may alter the signaling balance in the cell, potentially enhancing the activity of NARG2 as it participates in compensatory or interrelated pathways. | ||||||