NAGS Inhibitors
Chemical inhibitors of NAGS, also known as N-acetylglutamate synthase inhibitors, encompass a range of substances that indirectly influence the activity of this enzyme. The indirect approach to inhibition includes competition with substrates, interference with cofactors, and modulation of the urea cycle or related metabolic pathways. For example, L-Norvaline and L-Ornithine can compete with or provide feedback to the metabolic pathway that NAGS is part of, thus affecting its activity. Modulators such as Methylene Blue and Sodium Benzoate do not directly target NAGS but can influence the metabolic demand on the urea cycle, which indirectly affects the function of NAGS.
The indirect inhibition of NAGS can also involve broader cellular processes such as protein synthesis, cellular energy status, and gene expression. Compounds like Cycloheximide and Tunicamycin interfere with the biosynthesis and proper folding of proteins, including those involved in the urea cycle, which may result in decreased NAGS function. Similarly, Retinoic Acid can alter gene expression, affecting the synthesis of NAGS. Agents such as Chloroquine and Rapamycin affect cellular degradation pathways like autophagy and proteasomal degradation, which can modulate the turnover rate of NAGS or its regulatory proteins.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Norvaline | 6600-40-4 | sc-476585 sc-476585A sc-476585B sc-476585C sc-476585D | 5 g 25 g 100 g 250 g 1 kg | $32.00 $94.00 $228.00 $520.00 $1873.00 | ||
An analog of the amino acid L-valine that can compete with L-arginine, potentially reducing the availability of L-arginine for NAGS and thus its activity. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
A redox dye that can interfere with electron transport chains and mitochondrial function, potentially disrupting the energy status of the cell and the urea cycle, where NAGS functions. | ||||||
Sodium benzoate | 532-32-1 | sc-251009 | 250 g | $21.00 | ||
A substance that can reduce the ammonia load in the body by conjugation with glycine to form hippurate, thereby potentially influencing the regulation of the urea cycle and NAGS activity. | ||||||
1,5-Anhydro-D-sorbitol | 154-58-5 | sc-216143 sc-216143A sc-216143B sc-216143C | 100 mg 1 g 2 g 5 g | $298.00 $431.00 $662.00 $1046.00 | ||
A compound that can conjugate with glutamine to form phenylacetylglutamine, which is excreted in urine, potentially lowering the demand on the urea cycle and indirectly affecting NAGS activity. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
An antipsychotic known to affect glutamate neurotransmission, which could alter nitrogen metabolism and indirectly affect NAGS. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
An anticonvulsant that can influence amino acid metabolism and urea cycle function, potentially altering NAGS activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
An inhibitor of protein biosynthesis that can indirectly affect NAGS by limiting the synthesis of enzymes in the urea cycle, including NAGS itself. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An inhibitor of N-linked glycosylation that can impair the proper folding and function of membrane proteins, potentially affecting NAGS stability or localization. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A derivative of vitamin A that influences cell differentiation and gene expression, which could indirectly affect NAGS expression or activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
A agent in research known to affect lysosomal function and autophagy, potentially leading to altered NAGS degradation. | ||||||