Na+/K+-ATPase α3 Activators
The chemical class known as Na+/K+-ATPase α3 activators encompasses a variety of compounds that modulate the activity of the Na+/K+-ATPase α3 isoform. These activators play crucial roles in regulating ion transport across cell membranes, impacting various cellular processes and signaling cascades. Ouabain, Digitoxin, Bufalin, Marinobufagenin, Resibufogenin, and 5β-Pregnan-3,20-dione are cardiac glycosides that directly activate Na+/K+-ATPase α3 by interacting with its extracellular domain. This direct activation enhances the active transport of sodium and potassium ions, influencing cellular excitability and signaling pathways beyond their classical roles. Urea and Escin, while having different chemical structures, share the ability to directly activate Na+/K+-ATPase α3. Their interactions with the extracellular domain enhance ion transport, impacting cellular processes and signaling cascades.
CGS 21680, an adenosine A2A receptor agonist, indirectly activates Na+/K+-ATPase α3 by modulating adenosine receptor signaling. This indirect activation influences cellular processes like neurotransmission and cardiovascular function, demonstrating the interconnectedness of signaling pathways. Cysteamine, Amphotericin B, and α-Lipoic Acid act as indirect activators by influencing cellular redox status, oxidative stress responses, and membrane integrity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Digitoxin | 71-63-6 | sc-207577 sc-207577A sc-207577B sc-207577C sc-207577D | 250 mg 500 mg 1 g 5 g 10 g | $112.00 $186.00 $319.00 $1102.00 $2040.00 | 2 | |
Digitoxin, like ouabain, is a cardiac glycoside that directly activates Na+/K+-ATPase α3. Its interaction with the extracellular domain of Na+/K+-ATPase α3 enhances ion transport, modulating cellular functions and signaling pathways. Digitoxin's impact on sodium and potassium gradients across the cell membrane can influence cellular excitability and signaling, contributing to its pharmacological effects. | ||||||
Bufalin | 465-21-4 | sc-200136 sc-200136A sc-200136B sc-200136C | 10 mg 25 mg 50 mg 100 mg | $99.00 $204.00 $341.00 $544.00 | 5 | |
Bufalin, a component of toad venom, directly activates Na+/K+-ATPase α3 by interacting with its extracellular domain. This direct activation enhances the ion transport function of Na+/K+-ATPase α3, affecting cellular processes and signaling cascades. Bufalin's role in ion homeostasis can influence cellular excitability and contribute to its broader physiological effects. | ||||||
Resibufogenin | 465-39-4 | sc-202788 | 10 mg | $321.00 | 2 | |
Resibufogenin, another bufadienolide, directly activates Na+/K+-ATPase α3 by interacting with its extracellular domain. This direct activation enhances the ion transport function of Na+/K+-ATPase α3, impacting cellular processes and signaling cascades. Resibufogenin's modulation of ion homeostasis can influence cellular excitability and contribute to its broader physiological effects. | ||||||
5β-Dihydro Progesterone | 128-23-4 | sc-210426 | 100 mg | $234.00 | ||
5β-Pregnan-3,20-dione is a steroid that has been shown to directly activate Na+/K+-ATPase α3. Its interaction with the extracellular domain of Na+/K+-ATPase α3 enhances ion transport, modulating cellular functions and signaling pathways. The impact of 5β-Pregnan-3,20-dione on ion homeostasis can influence cellular excitability and contribute to its broader physiological effects. | ||||||
Urea | 57-13-6 | sc-29114 sc-29114A sc-29114B | 1 kg 2 kg 5 kg | $31.00 $43.00 $78.00 | 17 | |
Urea has been identified as a direct activator of Na+/K+-ATPase α3. Its precise mechanism of action is linked to the enhancement of the ion transport function of Na+/K+-ATPase α3, impacting cellular processes and signaling cascades. The influence of urea on ion homeostasis can contribute to its diverse physiological effects, beyond its conventional role as a metabolic waste product. | ||||||
Escin | 6805-41-0 | sc-221596 sc-221596A sc-221596B | 1 g 5 g 10 g | $68.00 $238.00 $286.00 | 5 | |
Escin, a natural mixture of saponins, has been reported to directly activate Na+/K+-ATPase α3. Its interaction with the extracellular domain of Na+/K+-ATPase α3 enhances ion transport, influencing cellular functions and signaling pathways. Escin's impact on ion homeostasis can contribute to its diverse physiological effects, and its potential therapeutic applications are being explored. | ||||||
CGS 21680 Hydrochloride | 124431-80-7 | sc-211062 sc-211062A | 10 mg 50 mg | $292.00 $1044.00 | 7 | |
CGS 21680 is an adenosine A2A receptor agonist that has been shown to indirectly activate Na+/K+-ATPase α3. By influencing adenosine receptors, CGS 21680 modulates signaling cascades that impact Na+/K+-ATPase α3 activity and ion transport. This indirect activation contributes to cellular processes influenced by Na+/K+-ATPase α3, such as neurotransmission and cardiovascular function. | ||||||
Cysteamine | 60-23-1 | sc-217991 sc-217991A sc-217991B | 5 g 25 g 50 g | $89.00 $238.00 $442.00 | 1 | |
Cysteamine indirectly activates Na+/K+-ATPase α3 by influencing cellular redox status and signaling pathways. Its impact on oxidative stress and related signaling cascades can modulate Na+/K+-ATPase α3 activity and ion transport. This indirect activation contributes to the cellular effects of cysteamine, including its role in lysosomal function and potential therapeutic applications in various conditions. | ||||||
Amphotericin B | 1397-89-3 | sc-202462 sc-202462A sc-202462B | 100 mg 500 mg 1 g | $70.00 $142.00 $223.00 | 10 | |
Amphotericin B indirectly activates Na+/K+-ATPase α3 by modulating membrane integrity and cellular ion balance. Its influence on membrane permeability can impact Na+/K+-ATPase α3 function and ion transport. This indirect activation contributes to the broader antifungal effects of amphotericin B, highlighting the interconnectedness of membrane integrity and ion homeostasis in cellular responses. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
α-Lipoic Acid has been reported to indirectly activate Na+/K+-ATPase α3 by modulating cellular redox status and signaling pathways. Its impact on oxidative stress responses can influence Na+/K+-ATPase α3 activity and ion transport. This indirect activation contributes to the diverse physiological effects of α-lipoic acid, including its potential antioxidant and metabolic regulatory properties. | ||||||