Escin (CAS 6805-41-0)
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Escin is a mixture of triterpene saponins derived from the seeds of the horse chestnut tree. It functions as a surfactant, reducing the surface tension of water and allowing it to penetrate and disperse substances more effectively. Escin′s mechanism of action involves interacting with cell membranes, disrupting their structure and function. This leads to increased permeability and fluidity of the membranes, affecting the transport of ions and molecules across the cell. Escin may inhibit enzymes involved in inflammation and edema, potentially modulating cellular signaling pathways. Its ability to interact with lipid bilayers and modulate cellular processes may be useful for studying membrane biology and cellular physiology in experimental applications.
Escin (CAS 6805-41-0) References
- Endothelia-Targeting Protection by Escin in Decompression Sickness Rats. | Zhang, K., et al. 2017. Sci Rep. 7: 41288. PMID: 28112272
- Molecular targets and anti-cancer potential of escin. | Cheong, DHJ., et al. 2018. Cancer Lett. 422: 1-8. PMID: 29474858
- Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. | Gallelli, L. 2019. Drug Des Devel Ther. 13: 3425-3437. PMID: 31631970
- Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats. | Suryavanshi, SV. and Kulkarni, YA. 2020. Life Sci. 254: 117777. PMID: 32407839
- Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin. | Gallelli, L., et al. 2020. J Clin Pharmacol. 60: 815-825. PMID: 32441805
- Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine. | Idris, S., et al. 2020. J Basic Clin Physiol Pharmacol. 31: PMID: 32649293
- Escin ameliorates the impairments of neurological function and blood brain barrier by inhibiting systemic inflammation in intracerebral hemorrhagic mice. | Ding, YX., et al. 2021. Exp Neurol. 337: 113554. PMID: 33309746
- Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug. | Gallelli, L., et al. 2021. Drug Des Devel Ther. 15: 699-704. PMID: 33658760
- Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles. | Tucker, IM., et al. 2022. J Colloid Interface Sci. 626: 305-313. PMID: 35792461
- Escin suppresses immune cell infiltration and selectively modulates Nrf2/HO-1, TNF-α/JNK, and IL-22/STAT3 signaling pathways in concanavalin A-induced autoimmune hepatitis in mice. | Elshal, M. and Hazem, SH. 2022. Inflammopharmacology. 30: 2317-2329. PMID: 36063304
- Anti-obesity effect of escin: a study on high-fat diet-induced obese mice. | Zhang, QH., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 7797-7812. PMID: 36394728
- Escin's Multifaceted Therapeutic Profile in Treatment and Post-Treatment of Various Cancers: A Comprehensive Review. | Fazliev, S., et al. 2023. Biomolecules. 13: PMID: 36830684
- Escin enhanced the efficacy of sorafenib by autophagy-mediated apoptosis in lung cancer cells. | Hussain, Y., et al. 2023. Phytother Res.. PMID: 37468281
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Escin, 1 g | sc-221596 | 1 g | $68.00 | |||
Escin, 5 g | sc-221596A | 5 g | $238.00 | |||
Escin, 10 g | sc-221596B | 10 g | $286.00 |