Na+/K+-ATPase α3 Inhibitors
Na+/K+-ATPase α3 inhibitors constitute a diverse group of chemicals with varying mechanisms that impede the normal functioning of the ion transport enzyme. Direct binding to the extracellular domain of Na+/K+-ATPase α3 characterizes the inhibitory actions of Ouabain, bufalin, digoxin, palytoxin, oleandrin, marinobufagenin, vanadate, proscillaridin A, digitoxin, and cantharidin. Each of these direct inhibitors exhibits a unique mode of action in disrupting ion transport processes across the cell membrane. Additionally, indirect inhibition is observed with chemicals like 3,5,3'-Triiodothyronine (T3) and arsenic trioxide. T3 influences gene expression, specifically regulating genes involved in ion transport through transcriptional control, while arsenic trioxide induces oxidative stress, impacting redox signaling pathways. The inclusion of these indirect inhibitors underscores the intricate regulatory networks influencing Na+/K+-ATPase α3 activity.
Common among these inhibitors is the modulation of specific signaling pathways, connecting them to crucial cellular responses like proliferation, differentiation, stress responses, and inflammation. The implicated pathways include MAPK, Wnt/β-catenin, JNK, PI3K/Akt, NF-κB, cAMP/PKA, mTOR, Hedgehog, and Nrf2/ARE.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain is a cardiac glycoside that directly inhibits Na+/K+-ATPase α3 by binding to its extracellular domain. This binding disrupts the enzyme's ability to pump sodium and potassium ions across the cell membrane, leading to an intracellular accumulation of sodium ions and a subsequent increase in calcium levels. | ||||||
L-3,3′,5-Triiodothyronine, Sodium Salt | 55-06-1 | sc-205725 | 250 mg | $115.00 | ||
3,5,3'-Triiodothyronine (T3), a thyroid hormone, functions as an indirect inhibitor of Na+/K+-ATPase α3 by influencing gene expression. T3 binds to nuclear receptors, leading to the transcriptional regulation of genes involved in ion transport. This modulation affects intracellular ion concentrations and influences cellular signaling pathways. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide functions as an indirect inhibitor of Na+/K+-ATPase α3 by influencing redox signaling. It induces oxidative stress, leading to the activation of stress-responsive pathways. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin, a natural toxin, functions as a direct inhibitor of Na+/K+-ATPase α3 by binding to the enzyme and disrupting ion transport processes. | ||||||