Na+/K+-ATPase α1 Activators
Na+/K+-ATPase α1 activators belong to a chemical class of compounds that exert influence over the activity of the Na+/K+-ATPase α1 isoform, a vital transmembrane enzyme found in the plasma membrane of most animal cells. This enzyme plays an integral role in maintaining cellular ion balance by actively transporting sodium ions (Na+) out of the cell and potassium ions (K+) into the cell against their respective electrochemical gradients. This ion transport is essential for numerous physiological processes, including the generation of membrane potential, regulation of cell volume, and the establishment of ion gradients crucial for nerve conduction and muscle contraction. Na+/K+-ATPase α1 activators are characterized by their capacity to enhance the enzyme's catalytic activity, resulting in increased sodium-potassium exchange across the cell membrane.
Activation of Na+/K+-ATPase α1 involves a series of conformational changes and phosphorylation events, and these activators can modulate this process through various mechanisms. Some compounds may directly bind to specific sites on the enzyme, leading to increased affinity for substrate ions or altered enzyme kinetics. Others may indirectly influence Na+/K+-ATPase α1 activity by modifying intracellular signaling pathways that regulate the enzyme's phosphorylation status.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
This phospholipid can modulate Na^+/K^+-ATPase activity by enhancing the enzyme's affinity for ATP. It may facilitate the functional insertion of the enzyme into the lipid bilayer, thus optimizing its activity. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
An omega-3 fatty acid, EPA has been demonstrated to boost Na^+/K^+-ATPase activity in certain studies. It's believed that omega-3 fatty acids can integrate into cell membranes, influencing membrane fluidity and potentially enhancing enzyme activity. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
Another omega-3 fatty acid, DHA has been proposed to enhance Na^+/K^+-ATPase activity possibly by modifying the membrane's lipid environment, which can influence enzyme conformation and function. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
The spicy component of chili peppers, capsaicin has been observed to elevate Na^+/K^+-ATPase activity in certain settings, potentially by influencing cellular calcium dynamics and signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Derived from turmeric, curcumin has been indicated in some studies to enhance Na^+/K^+-ATPase activity. Its mechanism may be related to its antioxidant properties or direct interactions with cellular signaling pathways. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
This essential micronutrient has been reported to boost Na^+/K^+-ATPase activity. It's believed that selenium plays a role in maintaining the integrity and function of membrane-bound enzymes. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
An essential trace element, zinc can modulate the activity of Na^+/K^+-ATPase in certain contexts. It might act as a cofactor for the enzyme or influence cell signaling pathways that regulate enzyme activity. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $64.00 $72.00 $214.00 $683.00 $1173.00 $3504.00 | 16 | |
Primarily secreted by the pineal gland, melatonin has been shown in some experimental models to modulate Na^+/K^+-ATPase activity, potentially through its antioxidant properties or interactions with cellular signaling pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
A stimulant of the central nervous system, under certain conditions, caffeine has been shown to modulate Na^+/K^+-ATPase activity. The exact mechanism remains to be fully understood but might involve cAMP signaling or calcium dynamics. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenolic compound found in grapes and red wine, resveratrol has been suggested in some studies to enhance Na^+/K^+-ATPase activity, potentially through its antioxidant properties or activation of specific cell signaling pathways. | ||||||