Date published: 2026-4-25

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N-Ras Inhibitors

N-Ras inhibitors belong to a specialized chemical class designed to target and modulate the activity of N-Ras proteins. N-Ras is a member of the Ras family of small GTPases, which play crucial roles in cell signaling pathways regulating cell growth, proliferation, and differentiation. The inhibitors are specifically designed to interfere with the function of N-Ras by blocking its activation or downstream signaling pathways. The N-Ras inhibitors typically work by binding to specific regions of the N-Ras protein, thereby disrupting its normal interactions with other cellular components and preventing its activation. By doing so, these inhibitors aim to hinder the transmission of signals that could lead to abnormal cell growth and division, which is particularly important in the context of cancer, where aberrant Ras signaling is often implicated in tumor development and progression. The development of N-Ras inhibitors is a result of extensive research and efforts to target oncogenic mutations and dysregulated pathways. These inhibitors are designed with high selectivity and specificity to N-Ras, allowing them to effectively inhibit its function without affecting other important cellular processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

17-AAG

75747-14-7sc-200641
sc-200641A
1 mg
5 mg
$67.00
$156.00
16
(2)

17-AAG (CAS 75747-14-7) is a chemical compound known for its inhibition of N-Ras. It functions as a potent and selective inhibitor, targeting the N-Ras protein's activity and interfering with its signaling pathways.

Tipifarnib

192185-72-1sc-364637
10 mg
$720.00
(0)

Tipifarnib is a farnesyltransferase inhibitor that was being studied for its potential to block the signaling pathway of N-Ras.

Lonafarnib

193275-84-2sc-482730
sc-482730A
5 mg
10 mg
$173.00
$234.00
(0)

Like Tipifarnib, Lonafarnib is another farnesyltransferase inhibitor that aims to prevent the activation of N-Ras.

Farnesyl thiosalicylic acid

162520-00-5sc-205322
sc-205322A
1 mg
5 mg
$61.00
$82.00
15
(1)

Salirasib is a farnesyltransferase inhibitor that targets N-Ras by preventing its prenylation, which is essential for its activation.

BAY 869766

923032-37-5sc-364427
sc-364427A
5 mg
10 mg
$245.00
$428.00
1
(1)

This compound was under investigation as an allosteric N-Ras inhibitor, aiming to block the protein's function.

Manumycin A

52665-74-4sc-200857
sc-200857A
1 mg
5 mg
$219.00
$634.00
5
(1)

Manumycin A is a natural product that acts as a farnesyltransferase inhibitor, with potential activity against N-Ras.