MYLK3 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates the retinoic acid receptor (RAR) pathway, which in turn can influence myosin light chain kinase (MYLK) family members including MYLK3. MYLK3 plays a crucial role in myosin phosphorylation, enabling muscle contraction. Activation of the RAR pathway by retinoic acid can indirectly enhance the functional activity of MYLK3 by influencing the MYLK family members. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid is a cofactor for prolyl hydroxylase. This enzyme hydroxylates proline residues in collagen, which is important for myocardial structure and function. Given MYLK3's role in myocardial contraction, enhanced myocardial function through ascorbic acid could logically lead to enhanced MYLK3 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor for matrix metalloproteinases, which are involved in extracellular matrix remodeling. This can affect the mechanical properties of cardiac tissues and could indirectly enhance MYLK3's functional activity by modulating the mechanical environment in which it operates. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine increases intracellular calcium levels and MYLK3 is activated by calcium-calmodulin. Thus, caffeine can enhance the activity of MYLK3 by increasing the availability of its activator, calcium. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit phosphodiesterases, which break down cAMP. Elevated cAMP levels can lead to increased intracellular calcium, which activates MYLK3. Thus, EGCG can potentially enhance MYLK3 activity by increasing calcium availability. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol can influence intracellular calcium levels, which are crucial for MYLK3 activation. Thus, estradiol can enhance MYLK3 activity by modulating calcium availability. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP levels can lead to increased intracellular calcium, which activates MYLK3. Thus, forskolin can enhance MYLK3 activity by increasing calcium availability. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that paradoxically can increase intracellular calcium levels under certain conditions. As MYLK3 is activated by calcium-calmodulin, increased calcium can enhance MYLK3 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) can increase intracellular cAMP levels, which can lead to increased intracellular calcium, a known activator of MYLK3. Thus, PGE2 can enhance MYLK3 activity by increasing calcium availability. | ||||||