MYL2 Activators
MYL2, also known as myosin regulatory light chain 2, is a protein that plays a crucial role in muscle contraction. The functional activity of MYL2 can be enhanced by several chemicals that influence specific signaling pathways or cellular processes. For instance, chemicals such as Phorbol 12-Myristate 13-Acetate (PMA), Forskolin, Epinephrine, Norepinephrine, Dopamine, and Isoproterenol activate signaling pathways leading to the increased production of cyclic AMP (cAMP) or directly increase its levels. This, in turn, activates Protein Kinase A (PKA), a kinase known to phosphorylate MYL2 and enhance its activity.
Additionally, chemicals such as IBMX, Cilostazol, Rolipram, and Milrinone function as phosphodiesterase inhibitors, preventing the breakdown of cAMP and thus increasing its levels in cells. This elevated level of cAMP leads to the activation of PKA, which can phosphorylate MYL2, thereby enhancing its function. Lastly, Pilocarpine and Carbachol, as cholinergic agonists, lead to an increase in intracellular calcium levels. This elevation in calcium activates calmodulin, which in turn can activate MYL2. Thus, the activity of MYL2 can be directly or indirectly enhanced by these specific chemicals through their influences on cellular signaling pathways or processes involved in its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which is involved in the regulation of MYL2 by phosphorylation. The activation of PKC can enhance the functional activity of MYL2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases the levels of cyclic AMP (cAMP) in cells. The increase in cAMP activates PKA, which can phosphorylate MYL2 and enhance its activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adrenergic receptors, leading to activation of G-proteins and subsequent increase in cAMP levels. The increase in cAMP activates PKA, which can phosphorylate and activate MYL2. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Similar to epinephrine, norepinephrine activates adrenergic receptors, leading to an increase in cAMP levels. The rise in cAMP activates PKA, which can phosphorylate and enhance MYL2 activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, through its receptors, can increase cAMP levels, leading to PKA activation. PKA can phosphorylate MYL2 and enhance its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist. Its activation of these receptors leads to an increase in cAMP levels, subsequently activating PKA which can phosphorylate and activate MYL2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor, preventing the breakdown of cAMP and thus increasing its levels. The elevated cAMP activates PKA which can phosphorylate MYL2, enhancing its activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol is a selective inhibitor of phosphodiesterase 3 (PDE3), which increases cAMP levels. The increased cAMP activates PKA that can phosphorylate MYL2, enhancing its function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of PDE4, leading to increased cAMP levels. The elevated cAMP activates PKA which can phosphorylate MYL2, enhancing its activity. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a potent and selective inhibitor of PDE3, which increases the levels of cAMP. The increased cAMP levels activate PKA, which can phosphorylate MYL2, enhancing its function. | ||||||