μ-protocadherin Activators
μ-protocadherin activators, often simply referred to as μ-Pcdh activators, represent a class of chemical compounds that have garnered significant interest within the realm of molecular biology and neurobiology due to their crucial role in modulating neural connectivity and cellular interactions. Protocadherins are a family of cell adhesion molecules primarily expressed in the nervous system, where they play a pivotal role in mediating selective neuronal connections and synapse formation. μ-protocadherins, a subgroup of the protocadherin family, are particularly notable for their involvement in specifying and maintaining the precise wiring of neurons in the brain. These activators are designed to enhance the expression and function of μ-protocadherins, thereby influencing the specificity and plasticity of neural connections.
μ-protocadherin activators typically function by modulating the gene expression of μ-protocadherins. These compounds interact with specific cellular pathways and transcription factors, ultimately leading to an upregulation of μ-protocadherin genes. The increased expression of μ-protocadherins, in turn, promotes the formation of unique cell adhesion profiles on the surfaces of neurons. This heightened diversity of cell adhesion molecules is critical for neurons to recognize and establish connections with appropriate partners, enabling the formation of complex neural circuits. As such, μ-protocadherin activators are powerful tools for researchers studying neural development and synaptic plasticity, offering insights into the intricate processes that underlie learning, memory, and neural network refinement.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can upregulate Mu-protocadherin by binding to retinoic acid receptors, leading to the activation of gene transcription pathways that specifically elevate the expression of genes within the protocadherin cluster. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
HDAC inhibitor that has the capacity to activate histone acetylation, which can indirectly activate the expression of μ-protocadherin (PCDH19) by modifying the epigenetic landscape. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound can stimulate Mu-protocadherin expression by inhibiting DNA methyltransferases, thereby reducing genomic DNA methylation levels and allowing transcription factors greater access to the protocadherin gene promoter regions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor that activates the acetylation status of histones, potentially promoting epigenetic regulation and thereby activating the transcription and expression of μ-protocadherin (PCDH19). | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $109.00 $369.00 | 2 | |
NMDA receptor agonists like N-Methyl-D-Aspartate can activate neuronal signaling pathways, which may indirectly activate μ-protocadherin (PCDH19) by influencing synaptic transmission and plasticity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This polyphenol can stimulate Mu-protocadherin expression through its antioxidant properties, potentially leading to the activation of signaling pathways that promote gene transcription associated with cell adhesion and communication. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a GSK-3 inhibitor, and its use may indirectly activate μ-protocadherin (PCDH19) by modulating GSK-3-related pathways and downstream effects. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore that can activate intracellular calcium levels, potentially activating the function of μ-protocadherin (PCDH19) by triggering calcium-dependent cellular processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates cAMP levels, which can indirectly activate μ-protocadherin (PCDH19) by influencing various signaling pathways activated by cAMP. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can activate PKC, a protein kinase involved in cell adhesion and signaling. This activation may indirectly activate μ-protocadherin (PCDH19) by modulating PKC-related pathways. | ||||||