mTOR Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin directly activates mTOR by forming a complex with FKBP12, inhibiting the mTORC1 complex. This inhibition relieves negative feedback, leading to mTORC2 activation and phosphorylation of AKT at Ser473, indirectly activating mTOR. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1 is a dual mTORC1/mTORC2 inhibitor that directly inhibits mTOR. Paradoxically, prolonged treatment with Torin 1 can lead to feedback activation of mTORC2, enhancing mTOR signaling and promoting cell survival. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is a dual mTORC1/mTORC2 inhibitor that directly inhibits mTOR. Similar to Torin 1, extended exposure to AZD8055 can induce feedback activation of mTORC2, contributing to sustained mTOR signaling and cell survival. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is a dual mTORC1/mTORC2 inhibitor that directly inhibits mTOR. Prolonged treatment with PP242 can activate feedback loops, enhancing mTORC2 signaling and leading to increased phosphorylation of AKT at Ser473. | ||||||
OSI-027 | 936890-98-1 | sc-364557 sc-364557A | 10 mg 50 mg | $437.00 $1186.00 | 1 | |
OSI-027 is a selective mTORC1/mTORC2 inhibitor that directly inhibits mTOR. Prolonged treatment with OSI-027 may induce feedback activation of mTORC2, enhancing mTOR signaling and contributing to increased AKT phosphorylation. | ||||||
WYE-125132 | 1144068-46-1 | sc-364651 sc-364651A | 10 mg 50 mg | $510.00 $1536.00 | ||
WYE-125132 is a dual mTORC1/mTORC2 inhibitor that directly inhibits mTOR. Extended exposure to WYE-125132 can induce feedback activation of mTORC2, contributing to sustained mTOR signaling and increased AKT phosphorylation. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
Everolimus, similar to rapamycin, directly inhibits mTOR by forming a complex with FKBP12, inhibiting the mTORC1 complex. Prolonged exposure may induce feedback activation of mTORC2, contributing to sustained mTOR signaling. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 is an allosteric AKT inhibitor that indirectly activates mTOR. Inhibition of AKT releases negative feedback on mTORC1, leading to increased mTORC1 activity and subsequent activation of downstream signaling pathways. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
SC79 is an Akt activator that indirectly activates mTOR. SC79 activates Akt, which in turn activates mTORC1 through phosphorylation of TSC2. This leads to mTORC1 activation and downstream modulation of protein synthesis and cell growth. | ||||||
UPF 1069 | 1048371-03-4 | sc-361396 sc-361396A | 5 mg 25 mg | $91.00 $358.00 | 1 | |
UPF 1069 is an mTORC2 inhibitor that indirectly activates mTORC1. Inhibition of mTORC2 leads to feedback activation of mTORC1, enhancing downstream signaling cascades involved in protein synthesis and cell growth. | ||||||