Date published: 2025-10-15

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UPF 1069 (CAS 1048371-03-4)

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Alternate Names:
5-(2-oxo-2-phenylethoxy)-1(2H)-Isoquinolinone
Application:
UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor
CAS Number:
1048371-03-4
Molecular Weight:
279.29
Molecular Formula:
C17H13NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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UPF 1069 is a selective PARP-2 (poly(ADP-ribose) polymerase 2) inhibitor. UPF 1069 may act to induce apoptosis. The poly(ADP-ribose) polymerases (PARPs) encompass a group of enzymes known for their involvement in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.


UPF 1069 (CAS 1048371-03-4) References

  1. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.  |  Moroni, F., et al. 2009. Br J Pharmacol. 157: 854-62. PMID: 19422384
  2. Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.  |  He, JX., et al. 2010. Acta Pharmacol Sin. 31: 1172-80. PMID: 20676117
  3. Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance.  |  Gerace, E., et al. 2012. Eur J Neurosci. 36: 1993-2005. PMID: 22639866
  4. PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca(2+)-permeable AMPA receptors.  |  Gerace, E., et al. 2014. Neurobiol Dis. 70: 43-52. PMID: 24954469
  5. FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.  |  Yu, C., et al. 2016. Cell Death Differ. 23: 1873-1885. PMID: 27662363
  6. AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration.  |  Jang, KH., et al. 2017. Cell Death Dis. 8: e2526. PMID: 28055012
  7. Dual Inhibitors of PARPs and ROCKs.  |  Antolín, AA. and Mestres, J. 2018. ACS Omega. 3: 12707-12712. PMID: 30411017
  8. Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function.  |  Gui, B., et al. 2019. Proc Natl Acad Sci U S A. 116: 14573-14582. PMID: 31266892
  9. Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status.  |  Keung, MY., et al. 2020. J Clin Med. 9: PMID: 32235451
  10. NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter.  |  Okabe, K., et al. 2020. Front Cell Dev Biol. 8: 586179. PMID: 33330464
  11. Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.  |  Manic, G., et al. 2021. Cell Death Differ. 28: 2060-2082. PMID: 33531658
  12. Functional Drug Screening of Small Molecule Inhibitors of Epigenetic Modifiers in Refractory AML Patients.  |  Dennison, JL., et al. 2022. Cancers (Basel). 14: PMID: 36077629
  13. Roles of DNA damage repair and precise targeted therapy in renal cancer (Review).  |  Lai, Y., et al. 2022. Oncol Rep. 48: PMID: 36263616

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

UPF 1069, 5 mg

sc-361396
5 mg
$89.00

UPF 1069, 25 mg

sc-361396A
25 mg
$351.00