MTO1 Activators
Chemical activators of MTO1 can engage the protein's function in various ways, primarily by enhancing mitochondrial function and energy production, which are central to MTO1's role in mitochondrial protein synthesis. Coenzyme Q10, a key player in the mitochondrial electron transport chain, directly supports the energetic demands of MTO1's processes. Its involvement in energy production ensures that MTO1 has the required ATP to perform optimally. Similarly, NADH, a pivotal component in oxidative phosphorylation, raises the functional capacity of mitochondria, thereby providing MTO1 with an improved environment for carrying out protein synthesis.
Other activators, like Leucine, stimulate the mTOR pathway, augmenting MTO1's activity by promoting the assembly of the mitochondrial protein synthesis machinery. Alpha-lipoic acid and Pyrroloquinoline quinone (PQQ) contribute to mitochondrial biogenesis, thereby expanding the number of sites where MTO1 can operate. The increased mitochondrial mass effectively raises the platform for MTO1 to function. Meanwhile, compounds such as Epigallocatechin gallate (EGCG) and Resveratrol trigger AMPK and SIRT1 pathways respectively, both of which are known to enhance mitochondrial activity. Enhanced mitochondrial function from these activations supports MTO1's role in protein synthesis. Creatine and L-Carnitine, by boosting cellular energy levels and fatty acid transport into mitochondria, respectively, ensure that MTO1 has a steady supply of the substrates necessary for its activity. S-Adenosylmethionine (SAMe) provides essential methyl groups, which might be crucial for the methylation reactions within mitochondria that MTO1 could be involved in. Lastly, Nicotinamide mononucleotide (NMN) and Succinic acid, by contributing to NAD+ levels and the TCA cycle, respectively, maintain a robust mitochondrial environment conducive to the activation of MTO1's protein synthesis capabilities.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is involved in the mitochondrial electron transport chain which is directly related to the function of MTO1 in mitochondrial protein synthesis. Coenzyme Q10's role in energy production can activate MTO1 by enhancing mitochondrial function and thus protein synthesis. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
Leucine can activate the mammalian target of rapamycin (mTOR) pathway, which is crucial for protein synthesis. Since MTO1 is involved in mitochondrial protein synthesis, activation of the mTOR pathway can enhance MTO1's functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can activate AMP-activated protein kinase (AMPK), which is involved in cellular energy homeostasis. Activation of AMPK can lead to enhanced mitochondrial function, possibly increasing the activity of MTO1 in mitochondrial protein synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate sirtuin 1 (SIRT1), which can enhance mitochondrial function and biogenesis. Through the activation of SIRT1, resveratrol can promote MTO1 activity by improving mitochondrial protein synthesis. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid influences mitochondrial biogenesis and can activate MTO1 by increasing the overall mitochondrial capacity for protein synthesis, which is the primary function of MTO1. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NADH serves as a substrate in oxidative phosphorylation, which is tightly linked with mitochondrial function. An increase in NADH levels can enhance mitochondrial activity, thereby activating MTO1 by improving its protein synthesis capabilities. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $27.00 $77.00 | 2 | |
Creatine supplementation is known to enhance cellular energy levels, indirectly supporting mitochondrial energy metabolism where MTO1 functions. Increased energy metabolism can activate MTO1 by providing the energy required for its protein synthesis role. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
L-Carnitine facilitates the transport of fatty acids into mitochondria for beta-oxidation. Enhanced beta-oxidation can improve mitochondrial function and potentially activate MTO1 by increasing substrate availability for mitochondrial protein synthesis. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
PQQ can stimulate mitochondrial biogenesis through activation of cAMP response element-binding protein (CREB) and peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α). This can activate MTO1 by increasing mitochondrial protein synthesis. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
SAMe serves as a methyl donor in numerous methylation reactions, including those in mitochondria. By providing methyl groups, SAMe can enhance the methylation status within mitochondria, potentially activating MTO1 by supporting its role in protein synthesis. | ||||||