Date published: 2026-4-15

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MTH Antibodies

Santa Cruz Biotechnology delivers a wide array of MTH Antibodies for the detection and analysis of methylenetetrahydrofolate reductase (MTHFR). MTH Antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Methylenetetrahydrofolate reductase plays a central role in the folate metabolism pathway, converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is essential for DNA synthesis and repair. Variants in the MTHFR gene have been associated with various health conditions, including cardiovascular diseases and neural tube defects. Research focused on MTHFR continues to reveal new insights into metabolic disorders and potential therapeutic approaches. MTH monoclonal antibodies enable precise detection and quantification of MTHFR expression levels across diverse experimental conditions. Investigating MTHFR function and regulation advances our understanding of folate metabolism and its impact on human health. Understanding methylenetetrahydrofolate reductase activity patterns helps identify new therapeutic strategies for related disorders. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific knowledge of MTHFR and its role in human health and disease.

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MTH Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

MTH1 Antibody (H-1)

sc-271082mouse IgG1 κ38-197 (h)WB, IP, IF, ELISAm, r, h
4
(4)

MTH1 Antibody (A-11)

sc-373709mouse IgG3 κ87-117 (m)WB, IP, IF, ELISAm, r
1
(2)

MTH1 Antibody (E-2)

sc-374011mouse IgG2a κ87-117 (m)WB, IP, IF, ELISAm, r

new

(1)

MTH CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

MTH1 CRISPR/Cas9 KO Plasmid (h)

sc-403105hGene KnockoutGFP0
(0)

MTH1 HDR Plasmid (h)

sc-403105-HDRhHomology Directed RepairPuromycin0
(0)

MTH1 CRISPR/Cas9 KO Plasmid (m2)

sc-421739-KO-2mGene KnockoutGFP0
(0)

MTH1 HDR Plasmid (m2)

sc-421739-HDR-2mHomology Directed RepairPuromycin0
(0)

MTH siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

MTH1 siRNA (h)

sc-62647hGene SilencingN/A
2
(0)

MTH1 shRNA Plasmid (h)

sc-62647-SHhGene SilencingPuromycin
2
(0)

MTH1 shRNA (h) Lentiviral Particles

sc-62647-VhGene SilencingPuromycin
2
(0)

MTH1 siRNA (m)

sc-62648mGene SilencingN/A0
(0)

MTH1 shRNA Plasmid (m)

sc-62648-SHmGene SilencingPuromycin0
(0)

MTH1 shRNA (m) Lentiviral Particles

sc-62648-VmGene SilencingPuromycin0
(0)