mSHMT Activators

The chemical class of mSHMT Activators includes compounds that can indirectly influence mSHMT function through their involvement in the one-carbon metabolism pathway, cofactor supplementation, and regulation of substrate availability. mSHMT, being central to amino acid metabolism and one-carbon transfer, is sensitive to changes in cofactor levels and substrate availability.

Compounds such as Folic Acid, Vitamin B6, and Methotrexate, by influencing folate metabolism, could indirectly affect mSHMT activity. Folic acid and vitamin B6 serve as cofactors for mSHMT, enhancing its enzymatic function, while methotrexate, by inhibiting folate metabolism, could have indirect effects on mSHMT activity. Other compounds like S-Adenosylmethionine, Betaine, and Choline, which are involved in methyl group transfers and the methionine cycle, can also indirectly influence mSHMT activity. Homocysteine levels can impact methylation pathways, thereby affecting mSHMT.